gene

APC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

608Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

APC is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 402 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	APC
Full Name	APC
Chromosome	5q22.2
Protein Type	Gene
Function	is a tumor suppressor gene originally identified for its role in colorectal cancer, but increasingly recognized for its critical functions in the central nervous system.
Amino Acids	843 aa
Pathways	Akt, Autophagy, Epigenetic, Mapk, Mtor
UniProt ID	P25054
NCBI Gene ID	324
Ensembl ID	ENSG00000134982
GeneCards	APC
Human Protein Atlas	APC
Associated Diseases	Aging, Als, Cancer, Carcinoma, Colorectal Cancer, Tumor
Known Drugs/Compounds	rapamycin
Interactions	DEPTOR, LC3, CDK2, JUN, UBIQUITIN, RIPK1
KG Connections	608 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: APC — AlphaFold P25054 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    APC["APC"] -->|"regulates"| cancer["cancer"]
    APC["APC"] -->|"interacts"| Cancer["Cancer"]
    APC["APC"] -->|"interacts"| Als["Als"]
    APC["APC"] -->|"interacts"| Ms["Ms"]
    APC["APC"] -->|"regulates"| Fibrosis["Fibrosis"]
    APC["APC"] -->|"associated"| Cancer_1["Cancer"]
    OPTN["OPTN"] -->|"interacts"| APC["APC"]
    CASP3["CASP3"] -->|"regulates"| APC["APC"]
    AKT1["AKT1"] -->|"regulates"| APC["APC"]
    CALCOCO2["CALCOCO2"] -->|"regulates"| APC["APC"]
    style APC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (413)

Target	Relation	Type	Str
Cancer	activates	disease	0.95
Cancer	therapeutic_target	disease	0.95
CANCER	activates	gene	0.90
CANCER	therapeutic_target	gene	0.90
Cancer	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85
Tumor	inhibits	disease	0.85
CANCER	associated_with	gene	0.80
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Cancer	regulates	disease	0.75
Inflammation	activates	disease	0.75
Als	associated_with	disease	0.75
Colorectal Cancer	therapeutic_target	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Gastric Cancer	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
LC3	associated_with	gene	0.70
cancer	regulates	disease	0.70
PIK3CA	associated_with	gene	0.70
PROTEOSTASIS	stabilizes	phenotype	0.70
glutamate signaling	participates_in	pathway	0.70
Wnt	activates	pathway	0.70
GENES	inhibits	gene	0.70
DNA	therapeutic_target	gene	0.70
ATG	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
PI3K	targets	gene	0.65
PI3K	treats	gene	0.65
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65

Incoming (195)

Source	Relation	Type	Str
TP53	associated_with	gene	0.70
CDH1	regulates	gene	0.70
CDH1	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
RAS	associated_with	gene	0.70
P53	inhibits	gene	0.70
KRAS	associated_with	gene	0.70
OPTN	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
ATF6	regulates	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

APC

Understanding Entity Pages

Summary

Wiki Pages (21)

APC Gene

cbs-psp-daily-action-plan

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

GSK-3β in Neurodegeneration

Remyelination in Neurodegeneration

Adaptive Immunity in Neurodegeneration

Wnt-Beta-Catenin Signaling Dysfunction Hypothesis in Parkinson's Disease

Actin Cytoskeleton Dynamics in Neurodegeneration

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

Astrocyte-Mediated Neuroinflammation

Wnt Signaling in Neurodegeneration

GSK3-beta Protein

GSK3B (Glycogen Synthase Kinase 3 Beta)

GSK-3β

Centrosome

DVL3 — Dishevelled Segment Polarity Protein 3

FZD10 Gene

FZD8 Gene

wnt-beta-catenin-signaling-pathway