protein 1,391 words KG: APLP2PROTEIN 2026-03-29
kind:proteinsection:proteinstopic:alzheimerstopic:parkinsonsstate:published
Contents

APLP2 Protein

🔬 Protein Info
Gene SymbolAPLP2
Full NameAmyloid Beta Precursor-Like Protein 2
AliasesAmyloid Precursor-Like Protein 2
Chromosome15q24.2
Protein FamilyAPP protein family (APP, APLP1, APLP2)
Functionencodes a protein of approximately 763 amino acids.
Primary Expressionneurons, astrocytes, oligodendrocytes, and microglia, with regional distribution in cerebral cortex, hippocampus, cerebellum, thalamus, and hypothalam
Subcellular LocalizationPlasma membrane, synaptic vesicles, endosomes, Golgi
Molecular Weight~87 kDa (mature, after N-glycosylation)
Amino Acids723
UniProt IDQ06481
Ensembl IDENSG00000145087
GeneCardsAPLP2
Human Protein AtlasAPLP2
Protein AliasAPLP2, amyloid precursor-like protein 2
Associated DiseasesAls
InteractionsAKT, ADAM10, APP, ALZHEIMER'S DISEASE, APOPTOSIS, APLP1
KG Connections39 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (8)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
APOE3 (Apolipoprotein E3)
disease · Pages share 4 hypotheses
APOE2 (Apolipoprotein E2)
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses