protein 1,391 words KG: APLP2PROTEIN
Contents

APLP2 Protein

🔬 Protein Info
Gene SymbolAPLP2
Full NameAmyloid Beta Precursor-Like Protein 2
AliasesAmyloid Precursor-Like Protein 2
Chromosome15q24.2
Functionencodes a protein of approximately 763 amino acids.
Primary Expressionneurons, astrocytes, oligodendrocytes, and microglia, with regional distribution in cerebral cortex, hippocampus, cerebellum, thalamus, and hypothalam
Molecular Weight87 kDa
Amino Acids763 aa
UniProt ID[Q06481](https://www.uniprot.org/uniprot/Q06481)
Ensembl IDENSG00000145087
GeneCardsAPLP2
Human Protein AtlasAPLP2
Associated DiseasesAls
InteractionsADAM10, AGING, AKT, ALZHEIMER'S DISEASE, APLP1, APOPTOSIS
KG Connections39 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (13)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

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