Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aplp1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APLP1 |
| Full Name | Amyloid Beta Precursor-Like Protein 1 |
| Chromosome | 19q13.3 |
| Function | is a type I transmembrane glycoprotein expressed predominantly in the nervous system, where it participates in diverse cellular processes including synapse development, plasticity, and network exci... |
| Primary Expression | the central nervous system with particularly high levels in the hippocampus (especially CA1 pyramidal neurons and dentate gyrus granule cells), cerebr |
| Amino Acids | 770 aa |
| UniProt ID | [Q15804](https://www.uniprot.org/uniprot/Q15804) |
| Ensembl ID | ENSG00000105248 |
| GeneCards | APLP1 |
| Human Protein Atlas | APLP1 |
| Associated Diseases | Alzheimer's disease |
| Interactions | LAG3, AMYLOID, PARKINSON, MMP9, CLDN5, Sod1 |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
aplp1["<b>aplp1</b>"]
LAG3(["LAG3"])
aplp1 -->|"interacts_with"| LAG3
SYNUCLEIN["SYNUCLEIN"]
aplp1 -->|"interacts_with"| SYNUCLEIN
__SYNUCLEIN["alpha-SYNUCLEIN"]
aplp1 -->|"interacts_with"| __SYNUCLEIN
AMYLOID(["AMYLOID"])
aplp1 -->|"interacts_with"| AMYLOID
NEURONS["NEURONS"]
aplp1 -->|"activates"| NEURONS
Neurodegeneration{"Neurodegeneration"}
Neurodegeneration -->|"activates"| aplp1
APOE(["APOE"])
APOE -->|"interacts_with"| aplp1
style aplp1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| LAG3 | interacts_with | protein | 0.50 |
| SYNUCLEIN | interacts_with | concept | 0.50 |
| α-SYNUCLEIN | interacts_with | concept | 0.50 |
| AMYLOID | interacts_with | gene | 0.50 |
| LAG3 | activates | protein | 0.50 |
| NEURONS | activates | concept | 0.50 |
| DOPAMINERGIC | activates | concept | 0.50 |
| DOPAMINERGIC NEURONS | activates | concept | 0.50 |
| PARKINSON | activates | gene | 0.50 |
| Parkinson's Disease | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| PARKINSON'S | activates | concept | 0.50 |
| SYNUCLEIN | activates | concept | 0.50 |
| α-SYNUCLEIN | activates | concept | 0.50 |
| MMP9 | interacts_with | gene | 0.50 |
| CLDN5 | interacts_with | gene | 0.50 |
| Sod1 | interacts_with | gene | 0.50 |
| NATURAL COMPOUNDS | interacts_with | concept | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| CURCUMIN | interacts_with | concept | 0.50 |
| RESVERATROL | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | activates | disease | 0.50 |
| APOE | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||