| Gene Symbol | AQP4 |
| Aliases | AQP4PROTEIN |
| Chromosome | 18q11.2 |
| Protein Family | Aquaporin (AQP) family |
| Target Class | Ion Channel |
| Mechanism of Action | Water channel inhibitor or modulator |
| Primary Expression | Astrocytes (perivascular endfeet), Ependyma, Kidney collecting duct |
| Subcellular Localization | Astrocyte end-feet, perivascular, ependymal |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 34 kDa |
| Amino Acids | 323 aa |
| Pathways | Adaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway |
| UniProt ID | P55064 |
| Ensembl ID | ENSG00000171885 |
| GeneCards | AQP4 |
| Human Protein Atlas | AQP4 |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, ARM |
| Known Drugs/Compounds | TGN-020, quercetin, dasatinib, riluzole, MELATONIN |
| Interactions | CD19, MAX, EMD, CR2, TNF, BAX |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SASP-Driven Aquaporin-4 Dysregulation Glymphatic System-Enhanced Antibody Clearance Reve Aquaporin-4 Polarization Rescue |
| KG Connections | 1824 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |