protein 1,611 words KG: C1QBPROTEIN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

C1QB Protein — Complement Component 1 Q

🔬 Protein Info
Gene SymbolC1QB
Full NameC1QB — Complement Component 1Q Beta
AliasesC1QBPROTEIN
Chromosome1p36.12.
Protein FamilyC1q family
Protein TypeGene
FunctionMechanism
Primary Expressionthe liver as the main source of circulating C1q
Subcellular LocalizationSecreted, extracellular
Molecular Weight~26 kDa (245 amino acids)
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
UniProt IDP02787
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsMET, C1Q, SOD1, HSP27, CD47, SIRPA
KG Connections250 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.40
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (12)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (8)

Single-cell RNA sequencing analysis of human atherosclerotic
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in