| Gene Symbol | CFB |
| Full Name | Complement Factor B |
| Aliases | CFBPROTEIN |
| Protein Type | Protease |
| Function | Complement Factor B (CFB) is a serine protease that plays a critical role in the alternative pathway of the complement system. |
| Pathways | Alternative Complement Pathway, Glycolysis, Complement, Immune Response, Myelination |
| GeneCards | CFB |
| Human Protein Atlas | CFB |
| Three short consensus repeats (SCR) | N-terminal Ba region for C3b binding |
| Serine protease (SP) domain | Catalytic domain with His-Asp-Ser triad [1] |
| Factor D inhibitors | Under development for age-related diseases |
| Anti-CFB antibodies | Potential for modulating complement in neurodegeneration |
| Complement inhibitors | Eculizumab, ravulizumab target downstream complement |
| Associated Diseases | Als, Alzheimer |
| Interactions | CCL2, COMPLEMENT, Cytokine, CYTOKINES, GLAUCOMA, Hemoglobin |
| KG Connections | 92 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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