gene

GLAUCOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLAUCOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1047Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GLAUCOMA
Aliases	Open-angle glaucoma, Angle-closure glaucoma
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Interactions	SIRT6, PVALB, CYP46A1, ALZHEIMER, APOE, ASTROCYTES
KG Connections	514 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLAUCOMA["GLAUCOMA"] -->|"associated"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| STROKE["STROKE"]
    style STROKE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"regulates"| NEUROPROTECTION["NEUROPROTECTION"]
    style NEUROPROTECTION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| SIRT6["SIRT6"]
    style SIRT6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AHR["AHR"] -.->|"inhibits"| GLAUCOMA["GLAUCOMA"]
    style AHR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CFB["CFB"] -->|"activates"| GLAUCOMA["GLAUCOMA"]
    style CFB fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DEPRESSION["DEPRESSION"] -->|"contributes to"| GLAUCOMA["GLAUCOMA"]
    style DEPRESSION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| GLAUCOMA["GLAUCOMA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AXON["AXON"] -->|"associated"| GLAUCOMA["GLAUCOMA"]
    style AXON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style GLAUCOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (494)

Target	Relation	Type	Str
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Glaucoma	regulates	disease	0.65
Senescence	activates	disease	0.65
Aging	activates	disease	0.65
Glaucoma	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Glaucoma	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Glaucoma	inhibits	disease	0.65
Inflammation	contributes_to	disease	0.65
Ischemia	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Glaucoma	contributes_to	disease	0.65
Glaucoma	associated_with	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Glaucoma	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Glaucoma	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Hypertension	inhibits	disease	0.65
Depression	contributes_to	disease	0.65
Anxiety	contributes_to	disease	0.65
Obesity	contributes_to	disease	0.65
Multiple Sclerosis	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Stroke	contributes_to	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Als	contributes_to	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Retinopathy	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Hypertension	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Huntington	inhibits	disease	0.65

Incoming (553)

Source	Relation	Type	Str
CYP46A1	implicated_in	gene	0.80
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
RETINA	causes	brain_region	0.65
MICROGLIA	protects_against	cell_type	0.65
ASTROCYTES	protects_against	cell_type	0.65
GLUTAMATE	activates	phenotype	0.65
MLKL	protects_against	gene	0.65
HYPERTENSION	increases_risk	disease	0.65
AHR	inhibits	entity	0.60
AHR	regulates	entity	0.60
AHR	expressed_in	entity	0.60
CFB	activates	entity	0.60
DEPRESSION	contributes_to	entity	0.60
DEPRESSION	associated_with	entity	0.60
IL-18	activates	gene	0.60
NLRP3	associated_with	gene	0.60
C1Q	activates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
ATF3	regulates	gene	0.60
CHOP	regulates	gene	0.60
MTOR	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MITOCHONDRIA	protects_against	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GSH	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
ANXIETY	contributes_to	gene	0.60
TLR4	associated_with	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
STROKE	contributes_to	gene	0.60
MICROGLIA	regulates	gene	0.60
PIEZO1	contributes_to	gene	0.60
EXERCISE	regulates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
SIRT6	protects_against	gene	0.60
AGING	activates	gene	0.60
OVERVIEW	expressed_in	gene	0.60
STING1	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
AGING	associated_with	gene	0.60
MTOR	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLAUCOMA

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neuroprotection Strategies in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

NF-kB Signaling Pathway in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

ROCK1 Gene

FGF Signaling Pathway in Neurodegeneration

lmx1b

Complement-Mediated Synapse Loss

Kinesin-1 Heavy Chain Protein

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

LY03020 - Luye Pharma Phase 1 Trial

Retinal Biomarkers in Neurodegeneration

Diseases