| Gene Symbol | CHCHD2 |
| Aliases | CHCHD2PROTEIN |
| Chromosome | 7p13 |
| Protein Family | Coiled-Coil-Helix-Coiled-Coil-Helix (CHCHD) domain proteins |
| Protein Type | Protein |
| Function | is a small mitochondrial protein that plays critical roles in mitochondrial function, cellular metabolism, and Parkinson's disease (PD) pathogenesis. |
| Primary Expression | dopaminergic neurons of the substantia nigra pars compacta, explaining the selective vulnerability of these neurons in PD |
| Molecular Weight | 26 kDa |
| Amino Acids | 182 aa |
| Pathways | Mitophagy |
| UniProt ID | Search UniProt |
| GeneCards | CHCHD2 |
| Human Protein Atlas | CHCHD2 |
| Twin CX9C motif | Two Cys-X9-Cys sequences that form zinc-binding domains, enabling dimerization and interaction with other mitochondrial proteins |
| Coiled-coil Helix domains | Alpha-helical regions facilitating protein-protein interactions within the inner mitochondrial membrane |
| Associated Diseases | Aging, ALS, Amyotrophic Lateral Sclerosis, cardiovascular disease, Dementia, frontotemporal dementia |
| Interactions | AKT, ALS, AND, ASTROCYTE, ASTROCYTES, CHCHD10 |
| KG Connections | 187 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!