gene

CHCHD10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHCHD10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

0Hypotheses

1Analyses

50Outgoing

21Incoming

Summary

CHCHD10 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 20 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHCHD10
Full Name	Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10
Aliases	CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10
Chromosome	22q11.23
Protein Family	CHCH domain-containing protein family
Function	Together they stabilize the mitochondrial contact site and cristae organizing system (MICOS), which maintains cristae morphology essential for efficient OXPHOS (Genin et al., 2016).
Primary Expression	Motor cortex, Spinal cord, Mitochondria (widespread)
Subcellular Localization	the mitochondrial intermembrane space (IMS), where it plays a role in maintaining cristae morphology and oxidative phosp
Molecular Weight	14 kDa
Amino Acids	182 aa
UniProt ID	Q8WYQ3
NCBI Gene ID	400916
Ensembl ID	ENSG00000250479
OMIM	615903
GeneCards	CHCHD10
Human Protein Atlas	CHCHD10
Associated Diseases	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AUTOPHAGY, MITOCHONDRIAL DYSFUNCTION, PARKINSON'S DISEASE
Interactions	FUS, GBA, LRRK2, PARK7, PINK1, SNCA
KG Connections	127 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHCHD10 — AlphaFold Q8WYQ3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHCHD10["<b>CHCHD10</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    CHCHD10 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Ms{"Ms"}
    CHCHD10 -->|"therapeutic target"| Ms
    Als{"Als"}
    CHCHD10 -->|"associated with"| Als
    C21ORF2["C21ORF2"]
    CHCHD10 -->|"associated with"| C21ORF2
    NEK1["NEK1"]
    CHCHD10 -->|"associated with"| NEK1
    SOD1["SOD1"]
    CHCHD10 -->|"therapeutic target"| SOD1
    TBK1["TBK1"]
    CHCHD10 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    CHCHD10 -->|"implicated in"| neurodegeneration
    C21ORF2 -->|"associated with"| CHCHD10
    GENES["GENES"]
    GENES -->|"associated with"| CHCHD10
    DNA["DNA"]
    DNA -->|"therapeutic target"| CHCHD10
    style CHCHD10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.90
ALS	causes	disease	0.80
neurodegeneration	associated_with	disease	0.70
OPA1	regulates	gene	0.65
OPA1	causes	gene	0.65
TDP-43	activates	gene	0.65
TDP-43	inhibits	gene	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
NEURON	interacts_with	cell_type	0.65
APOPTOSIS	inhibits	phenotype	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
MITOCHONDRIAL DYSFUNCTION	causes	phenotype	0.65
MOTOR NEURONS	activates	cell_type	0.65
C21ORF2	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
SOD1	therapeutic_target	gene	0.60
TBK1	associated_with	gene	0.60
FUS	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARK7	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TBK1	interacts_with	gene	0.60
TGM2	interacts_with	gene	0.60
TMEM175	interacts_with	gene	0.60
VCP	interacts_with	gene	0.60
FUS	implicated_in	gene	0.60
SQSTM1	implicated_in	gene	0.60
TBK1	implicated_in	gene	0.60
VCP	implicated_in	gene	0.60
GRN	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
VCP	associated_with	gene	0.60
GRN	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
NEK1	interacts_with	gene	0.60
CHCHD2	associated_with	gene	0.60
cardiovascular disease	associated_with	disease	0.60
CHCHD2	interacts_with	gene	0.60
TDP43	interacts_with	gene	0.60
CHCHD2	protects_against	gene	0.60
neurodegeneration	protects_against	disease	0.60
CHCHD2	causes	gene	0.60
CHCHD2	co_expressed_with	gene	0.60
CHCHD2	implicated_in	gene	0.60

Incoming (21)

Source	Relation	Type	Str
ALS	causes	gene	0.70
PINK1	treats	gene	0.65
TDP-43	interacts_with	gene	0.65
C21ORF2	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
NEK1	associated_with	gene	0.60
CCNF	interacts_with	gene	0.60
ANXA11	causes	gene	0.60
CCNF	causes	gene	0.60
ANXA11	associated_with	gene	0.60
CCNF	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	therapeutic_target	gene	0.60
MATR3	associated_with	gene	0.60
ALS	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALS	interacts_with	gene	0.60
ALS	implicated_in	gene	0.60
ALS	protects_against	gene	0.60
SPINAL CORD	associated_with	brain_region	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHCHD10

Understanding Entity Pages

Summary

Wiki Pages (21)

CHCHD10 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

Mitochondrial Quality Control

Epigenetic Dysregulation in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

Synaptic Dysfunction in Neurodegeneration

Creatine for Neuroprotection

CBS/PSP Genetic Architecture

ftd-tdp43-pathway

RNASEK — Ribonuclease Kappa

Mechanistic Proposal: Pathologic synergy: The pathologic aggregation of...

CHCHD2 - Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2

Amyotrophic Lateral Sclerosis Hypothesis Rankings

Section 102: Proteostasis Network Dysregulation in CBS/PSP

Proteostasis Therapy CBS PSP

Genetic Risk Factors Across 4R-Tauopathies

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

TDP-43 (TAR DNA-Binding Protein 43) - Biomarker

CHCHD2 Protein