protein 1,195 words KG: DAB1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

DAB1 Protein

🔬 Protein Info
Gene SymbolDAB1
Full NameDisabled-1
Chromosome1p32-p31
Protein FamilyDisabled family (PFAM: PF03131)
Protein TypeAdaptor Protein
Functionis a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular LocalizationCytoplasm, Postsynaptic densities, Growth cones
Molecular Weight~82 kDa (625 amino acids)
Amino Acids625 aa
PathwaysDendritic Spine, Synaptic Plasticity
UniProt IDQ9UHQ2
NCBI Gene ID1600
Ensembl IDENSG00000170522
OMIM603448
GeneCardsDAB1
Human Protein AtlasDAB1
Associated DiseasesALS, Alzheimer, Autism, Bipolar, Depression
InteractionsPAFAH1B1, DCX, LIS1, CDK5, RELN, GAIN
KG Connections145 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in