protein 1,258 words KG: DAP12PROTEIN 2026-03-28
kind:proteinsection:proteinsstate:published
Contents

DAP12 Protein

🔬 Protein Info
Gene SymbolDAP12
AliasesTYROBP
Chromosome19q13.12.
Primary ExpressionHippocampus
Molecular Weight12 kDa
PathwaysPI3K
GeneCardsDAP12
Human Protein AtlasDAP12
N-terminal signal peptideResidues 1-19
Extracellular (EC) domainResidues 20-113
Transmembrane (TM) domainResidues 114-136
[TREM2](/genes/trem2)Direct binding
SIRPβ1Direct binding
TREM1Direct binding
Blocking receptorsDirect binding
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Nasu-Hakola Disease, disease, neurodegeneration
InteractionsTREM2, OVERVIEW, PSEN1, TYROBP, APP, SYK
KG Connections204 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (20)

Microglial TREM2-Independent Pathway Activation
Score: 0.46
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (9)

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3
molecular biology · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 3 hypotheses
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 3 hypotheses
Therapeutic Targets in Neurodegeneration
mechanism · Pages share 3 hypotheses
Sex Differences in Neurodegeneration
mechanism · Pages share 3 hypotheses