| Gene Symbol | DRD4PROTEIN |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | prefrontal cortex, hippocampus, and hypothalamus, where it modulates cognitive functions, atten |
| Subcellular Localization | ** | Plasma membrane, dendritic spines | |
| Molecular Weight | 55 kDa |
| GeneCards | DRD4PROTEIN |
| Human Protein Atlas | DRD4PROTEIN |
| Alternative splicing | Produces multiple isoforms with differential signaling properties |
| N-linked glycosylation sites | Located in the N-terminus for proper protein folding |
| Attention and cognition | Prefrontal cortex expression modulates working memory and attentional processes |
| Impulse control | Striatal and cortical expression influences response inhibition |
| Reward processing | Limbic system involvement in novelty-seeking and reward anticipation |
| Hormonal regulation | Hypothalamic expression modulates pituitary hormone release |
| Associated Diseases | Addiction, Opioid, SUD |
| Interactions | BDNF, DRD2, NEURODEGENERATION, NEUROINFLAMMATION, NEURON, OPRM1 |
| KG Connections | 72 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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