gene

OPRM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

Summary

OPRM1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Alzheimer, Anxiety, Dementia. Connected to 79 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OPRM1
Full Name	Mu-Opioid Receptor
Protein Type	Protein
Function	is a G protein-coupled receptor (GPCR) primarily known for its role in pain modulation, reward processing, and opioid drug responses[@minami1995].
Pathways	autophagy pathway
UniProt ID	Search UniProt
GeneCards	OPRM1
Human Protein Atlas	OPRM1
Layer	Components
Outer segment layer	Photoreceptor outer segments
Outer nuclear layer	Phot photoreceptor cell bodies
Outer plexiform layer	Photoreceptor synapses
Inner nuclear layer	Bipolar, horizontal, amacrine cells
Ganglion cell layer	Ganglion cell axons
Feature	Rods
Associated Diseases	Addiction, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
Interactions	OPRD1, GENES, PER, BDNF, DRD2, DRD4
KG Connections	102 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OPRM1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OPRM1["OPRM1"] -->|"associated"| Alzheimer["Alzheimer"]
    OPRM1["OPRM1"] -->|"therapeutic target"| Dementia["Dementia"]
    OPRM1["OPRM1"] -->|"associated"| Depression["Depression"]
    OPRM1["OPRM1"] -->|"associated"| Anxiety["Anxiety"]
    OPRM1["OPRM1"] -->|"associated"| Dementia_1["Dementia"]
    OPRM1["OPRM1"] -->|"interacts"| Dementia_2["Dementia"]
    MAOB["MAOB"] -->|"associated"| OPRM1["OPRM1"]
    GABRA1["GABRA1"] -->|"associated"| OPRM1["OPRM1"]
    CHAT["CHAT"] -->|"associated"| OPRM1["OPRM1"]
    CYP2D6["CYP2D6"] -->|"associated"| OPRM1["OPRM1"]
    style OPRM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (59)

Target	Relation	Type	Str
OPRD1	interacts_with	gene	0.80
Opioid	associated_with	disease	0.65
Addiction	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
SUD	associated_with	disease	0.64
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CHRNA5	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Epigenetic	therapeutic_target	pathway	0.60
Epigenetic	associated_with	pathway	0.60
CYP1A2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
Epigenetic	interacts_with	pathway	0.60
DEPRESSION	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PER	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
ADH1B	associated_with	gene	0.60
AND	associated_with	gene	0.60

Incoming (43)

Source	Relation	Type	Str
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CHRNA5	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
DRD4	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
CYP2C19	associated_with	gene	0.60
MTHFR	associated_with	gene	0.60
CYP1A2	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
ADH1B	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
AND	associated_with	gene	0.60
CYP3A5	associated_with	gene	0.60
PER	therapeutic_target	gene	0.60
BDNF	interacts_with	gene	0.50
DRD2	interacts_with	gene	0.50
DRD4	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OPRM1

Understanding Entity Pages

Summary

Wiki Pages (21)

OPRM1 — Mu-Opioid Receptor

OPRD1 — Delta-Opioid Receptor

ADCY3 — Adenylate Cyclase 3

OPRK1 — Kappa Opioid Receptor

Mu-Opioid Receptor Protein

NBEA — Neurobeachin

Mu Opioid Receptor (MOR) Neurons

Delta Opioid Receptor (DOR) Neurons

Intercalated Striatum Neurons

Lamina I Nociceptive Neurons

Spinal Cord Lamina I Neurons in Pain

slc30a8

Insular Cortex Neurons

Periaqueductal Gray (PAG) Neurons

Spinal Cord Lamina I Projection Neurons

Kappa-Opioid Receptor Protein

D3 Dopamine Receptor Protein

Olfactory Tubercle Neurons

D5 Dopamine Receptor Protein