Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OPIOID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OPIOID |
Knowledge base pages for this entity
graph TD
OPIOID["OPIOID"]
OPIOID -->|"inhibits"| Neurogenesis["Neurogenesis"]
OPIOID -->|"activates"| Microglia["Microglia"]
OPIOID -->|"activates"| Neuron["Neuron"]
OPIOID -->|"activates"| Macrophage["Macrophage"]
OPIOID -->|"target for"| Complement_System["Complement System"]
OPIOID -->|"target for"| T_Cell["T Cell"]
OPIOID -->|"target for"| Mast_Cell["Mast Cell"]
CRH["CRH"] -->|"activates"| OPIOID
DEPRESSION["DEPRESSION"] -->|"interacts"| OPIOID
SYNAPSE["SYNAPSE"] -->|"interacts"| OPIOID
P2X7["P2X7"] -->|"activates"| OPIOID
MICROGLIA["MICROGLIA"] -->|"activates"| OPIOID
TRKA["TRKA"] -->|"inhibits"| OPIOID
NGF["NGF"] -->|"target for"| OPIOID
GAIN["GAIN"] -->|"inhibits"| OPIOID| Target | Relation | Type | Str |
|---|---|---|---|
| Mast Cell | therapeutic_target | cell_type | 0.55 |
| Amygdala | associated_with | brain_region | 0.55 |
| Ventral Tegmental Area | associated_with | brain_region | 0.55 |
| Neurogenesis | inhibits | pathway | 0.55 |
| Microglia | activates | cell_type | 0.55 |
| Neuron | activates | cell_type | 0.55 |
| Macrophage | activates | cell_type | 0.55 |
| Neuron | associated_with | cell_type | 0.55 |
| Complement System | therapeutic_target | pathway | 0.55 |
| Microglia | therapeutic_target | cell_type | 0.55 |
| T Cell | therapeutic_target | cell_type | 0.55 |
| Macrophage | therapeutic_target | cell_type | 0.55 |
| Astrocyte | therapeutic_target | cell_type | 0.55 |
| Neuron | therapeutic_target | cell_type | 0.55 |
| Cortex | associated_with | brain_region | 0.55 |
| Spinal Cord | associated_with | brain_region | 0.55 |
| Neuron | inhibits | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FOXP2 | associated_with | gene | 0.65 |
| DRD2 | associated_with | gene | 0.65 |
| OPRM1 | associated_with | gene | 0.65 |
| BDNF | associated_with | gene | 0.65 |
| SLC6A4 | associated_with | gene | 0.65 |
| CHRNA5 | associated_with | gene | 0.65 |
| OVERVIEW | associated_with | gene | 0.65 |
| DRD4 | associated_with | gene | 0.65 |
| CRH | activates | gene | 0.65 |
| CRH | associated_with | gene | 0.65 |
| P2X7 | activates | gene | 0.65 |
| TRKA | inhibits | gene | 0.65 |
| NGF | therapeutic_target | gene | 0.65 |
| GAIN | inhibits | gene | 0.65 |
| NRP1 | therapeutic_target | gene | 0.65 |
| ADH1B | associated_with | gene | 0.65 |
| DEPRESSION | interacts_with | gene | 0.65 |
| SYNAPSE | interacts_with | gene | 0.65 |
| MICROGLIA | activates | gene | 0.65 |
| ATP | associated_with | gene | 0.65 |
| GABA | associated_with | gene | 0.65 |
| SYNAPSE | associated_with | gene | 0.65 |
| ENDOSOMES | inhibits | gene | 0.65 |
| ASTROCYTES | therapeutic_target | gene | 0.65 |
| COMPLEMENT | therapeutic_target | gene | 0.65 |
| MICROGLIA | therapeutic_target | gene | 0.65 |
| CYTOKINES | therapeutic_target | gene | 0.65 |
| Bdnf | associated_with | protein | 0.60 |
| Actin | inhibits | protein | 0.60 |
| Myosin | inhibits | protein | 0.60 |
| Ngf | therapeutic_target | protein | 0.60 |
| Cytokine | therapeutic_target | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||