| Gene Symbol | EPAS1 |
| Full Name | Endothelial PAS Domain Protein 1 |
| Aliases | HIF-2α |
| Chromosome | 2p21 |
| Protein Family | bHLH-PAS transcription factor family |
| Protein Type | Transcription Factor |
| Function | is a transcription factor that serves as the master regulator of cellular responses to hypoxia. |
| Primary Expression | Highest in endothelial cells, neurons, cardiomyocytes, type II pneumocytes |
| Subcellular Localization | Nucleus and cytoplasm (-regulated by oxygen) |
| Molecular Weight | ~96-118 kDa (depending on post-translational modifications) |
| Amino Acids | 870 aa |
| Exons | 16 |
| Pathways | Apoptosis, MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway |
| UniProt ID | Q9Y5Q3 |
| NCBI Gene ID | 2034 |
| Ensembl ID | ENSG00000177640 |
| OMIM | 603349 |
| GeneCards | EPAS1 |
| Human Protein Atlas | EPAS1 |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Interactions | MIRO1, CTSD, RB1, EIF2AK3, PRKN, BCL2L11 |
| KG Connections | 495 knowledge graph edges |
| Databases | GeneCardsHPASTRING |