protein 773 words KG: FERRITINH 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Ferritin Heavy Chain (FTH1)

🔬 Protein Info
Gene SymbolFERRITINH
Function1. Removes toxic free iron that catalyzes Fenton reactions
Molecular Weight21 kDa
PathwaysLABILE_IRON_POOL
GeneCardsFERRITINH
Human Protein AtlasFERRITINH
InteractorRelationship
[Ferritin Light Chain](/proteins/ferritin-l)Heteropolymer
[IRP1/2](/genes/ireb2)Post-transcriptional regulator
[Nrf2](/proteins/nrf2)Transcription factor
[Transferrin](/proteins/transferrin)Iron uptake
[Ferroportin](/genes/fpn1)Iron export
Associated DiseasesALS, Carcinoma, Hepatocellular Carcinoma, Parkinson's disease, Tumor, stroke
Known Drugs/Compoundsparicalcitol, dimethyl malonate
InteractionsGPX4, SIRT1, BECLIN1, NCOA4, UBE2N, TAK1
KG Connections324 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Ferroptosis Inhibition for α-Synuclein Neuroprotection
Score: 0.55
OPC differentiation blockade contributes to white matter deg
Score: 0.50
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (3)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40

See Also (6)

Brain & Behavior Research Foundation
institution · KG edge: expressed_in
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: regulates
PCBP1 Gene
gene · KG edge: binds
HSPA8 Gene
gene · KG edge: binds
CD63
gene · KG edge: associated_with

Knowledge Graph (11 edges)

FERRITINH binds HSPA8
FERRITINH regulates LABILE_IRON_POOL
FERRITINH expressed_in BRAIN
PCBP1 binds FERRITINH
PCBP1 regulates FERRITINH
ACONITASE1 regulates FERRITINH
ACONITASE2 regulates FERRITINH
PI3K regulates FERRITINH
H2O2 regulates FERRITINH
CD63 associated_with FERRITINH