Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HEPCIDIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HEPCIDIN |
| Function | Hepcidin is the master regulator of systemic iron homeostasis and a key hormone that controls iron absorption, recycling, and distribution throughout the body. |
| Pathways | Reactive Oxygen Species |
| GeneCards | HEPCIDIN |
| Human Protein Atlas | HEPCIDIN |
| Interactions | TRANSFERRIN, FERROPORTIN |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HEPCIDIN["HEPCIDIN"]
HEPCIDIN -->|"inhibits"| Ferroportin["Ferroportin"]
HEPCIDIN -->|"regulates"| FERROPORTIN["FERROPORTIN"]
HEPCIDIN -->|"regulates"| IRON_METABOLISM["IRON METABOLISM"]
HEPCIDIN -->|"regulates"| SLC40A1["SLC40A1"]
HEPCIDIN -->|"regulates"| FERRITINH["FERRITINH"]
HEPCIDIN -->|"activates"| HEPATOCYTES["HEPATOCYTES"]
HEPCIDIN -->|"regulates"| CYTOKINES["CYTOKINES"]
Iron_Load["Iron Load"] -->|"upregulates"| HEPCIDIN
TFR2["TFR2"] -->|"regulates"| HEPCIDIN
TRANSFERRIN["TRANSFERRIN"] -->|"interacts"| HEPCIDIN
FERROPORTIN -->|"interacts"| HEPCIDIN
APOE["APOE"] -->|"regulates"| HEPCIDIN
TFR1["TFR1"] -->|"regulates"| HEPCIDIN
GPX4["GPX4"] -->|"regulates"| HEPCIDIN
MAP2["MAP2"] -->|"regulates"| HEPCIDIN| Target | Relation | Type | Str |
|---|---|---|---|
| FERROPORTIN | regulates | entity | 0.95 |
| IRON METABOLISM | regulates | entity | 0.95 |
| Ferroportin | downregulates | entity | 0.93 |
| FERRITINH | regulates | protein | 0.70 |
| HEPATOCYTES | activates | concept | 0.50 |
| CYTOKINES | regulates | concept | 0.50 |
| Reactive Oxygen Species | regulates | process | 0.50 |
| Proteins | regulates | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRANSFERRIN | interacts_with | protein | 0.50 |
| FERROPORTIN | interacts_with | protein | 0.50 |
| APOE | regulates | gene | 0.50 |
| TFR1 | regulates | gene | 0.50 |
| GPX4 | regulates | gene | 0.50 |
| MAP2 | regulates | gene | 0.50 |
| TRANSFERRIN | regulates | protein | 0.50 |
| FERROPORTIN | regulates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Hepcidin-Iron Set Point Hypothesis | 0.511 | endocrinology | Does TRT-induced erythrocytosis actually |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||