| Gene Symbol | GNAI1PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the nervous system and plays critical roles in modulating neuronal signaling, synaptic transmission, and cellular responses to neurotransmitters |
| Subcellular Localization | - **Cys palmitoylation**: Additional membrane anchoring - **Phosphorylation**: S |
| GeneCards | GNAI1PROTEIN |
| Human Protein Atlas | GNAI1PROTEIN |
| N-terminal helix | Myristoylation site for membrane anchoring |
| Switch I region | Conformational changes between active/inactive states (residues 42-52) |
| Switch II region | Critical for GTP hydrolysis (residues 62-71) |
| Switch III region | Effector interaction interface (residues 87-97) |
| GTPase domain | Catalytic core for GTP hydrolysis (residues 35-190) |
| N-terminal glycine myristoylation | Required for membrane localization |
| Cys palmitoylation | Additional membrane anchoring |
| Phosphorylation | Serine/threonine phosphorylation regulates activity |
| Active state | Bound to GTP, able to interact with effectors |
| Associated Diseases | Als, Schizophrenia |
| Interactions | AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI2 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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