| Gene Symbol | GNAQPROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | to the Plasma membrane, Cytoplasm |
| GeneCards | GNAQPROTEIN |
| Human Protein Atlas | GNAQPROTEIN |
| GTP-binding domain | Binds GTP/GDP and undergoes conformational changes |
| Helical domain | Covers the nucleotide-binding pocket |
| Effector-binding interface | Interacts with downstream target proteins |
| Gq/11 | Activate phospholipase C-beta (PLCβ), leading to IP3/DAG production and calcium release |
| G12/13 | Activate RhoGEFs, regulating cytoskeletal remodeling and cell migration |
| Gi/o | Inhibit adenylate cyclase and activate GIRK channels |
| Associated Diseases | neurodegeneration |
| Interactions | STX17, GNA11, AKT, BRAF, PI3K, ERK1 |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |