gene

ERK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

943Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ERK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with AD, ALI, ALS. Connected to 498 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ERK1
Chromosome	16p11.2
Protein Type	Kinase
Function	is a serine/threonine protein kinase that plays a central role in intracellular signal transduction.
Primary Expression	various tissues, with particularly high levels in the brain where it participates in learning, memory, and neuronal plasticity
Subcellular Localization	**: Nuclear import/export controls signaling duration
Molecular Weight	44 kDa
Amino Acids	402 aa
Pathways	Akt, Apoptosis, Differentiation, G-Protein Coupled Receptor, Hedgehog
Ensembl ID	ENSG00000102882
GeneCards	ERK1
Human Protein Atlas	ERK1
N-lobe	ATP-binding pocket with glycine-rich loop
C-lobe	Catalytic site and substrate recognition surface
Associated Diseases	AD, ALI, AMI, Aging, Als, Alzheimer
Known Drugs/Compounds	curcumin, rapamycin, metformin
Interactions	FGF2, NRF2, KEAP1, AKT, GNAQ, STX17
KG Connections	943 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ERK1["ERK1"] -->|"activates"| Aging["Aging"]
    ERK1["ERK1"] -->|"interacts"| Cancer["Cancer"]
    ERK1["ERK1"] -->|"activates"| Ms["Ms"]
    ERK1["ERK1"] -->|"activates"| Als["Als"]
    ERK1["ERK1"] -->|"activates"| Alzheimer["Alzheimer"]
    ERK1["ERK1"] -.->|"inhibits"| Diabetes["Diabetes"]
    HSPA1A["HSPA1A"] -.->|"inhibits"| ERK1["ERK1"]
    FGF1["FGF1"] -->|"interacts"| ERK1["ERK1"]
    PRDX1["PRDX1"] -->|"activates"| ERK1["ERK1"]
    DNA["DNA"] -->|"activates"| ERK1["ERK1"]
    style ERK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (672)

Target	Relation	Type	Str
JNK	activates	gene	1.00
Als	activates	disease	1.00
ERK	activates	gene	1.00
Mapk	activates	pathway	1.00
Cancer	activates	disease	1.00
AKT	activates	gene	1.00
P38	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
PI3K	activates	gene	0.90
Apoptosis	activates	pathway	0.90
OXIDATIVE STRESS	activates	gene	0.90
Differentiation	activates	pathway	0.90
CANCER	activates	gene	0.90
Alzheimer	activates	disease	0.85
Als	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Cancer	therapeutic_target	disease	0.85
Inflammation	activates	disease	0.85
Tumor	activates	disease	0.85
Cancer	regulates	disease	0.85
Cardiac	activates	disease	0.85
MAPK signaling	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
JUN	activates	gene	0.80
P38	regulates	gene	0.80
ERK2	activates	gene	0.80
TNF	activates	gene	0.80
Apoptosis	regulates	pathway	0.80
ERK	regulates	gene	0.80
Apoptosis	inhibits	pathway	0.80
APOPTOSIS	activates	gene	0.80
TNF-Α	activates	gene	0.80
C-JUN	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
Autophagy	activates	pathway	0.80
Mapk	therapeutic_target	pathway	0.80
ALZHEIMER	activates	gene	0.80
Erk Signaling	activates	pathway	0.80
Inflammation	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
Ischemia	regulates	disease	0.75
Neurodegeneration	activates	disease	0.75
Stroke	regulates	disease	0.75
Als	regulates	disease	0.75
Carcinoma	activates	disease	0.75
Fibrosis	activates	disease	0.75
Tumor	inhibits	disease	0.75
Lymphoma	activates	disease	0.75
Neurodegeneration	regulates	disease	0.75
Glioblastoma	activates	disease	0.75

Incoming (271)

Source	Relation	Type	Str
KPNA2	interacts_with	protein	0.93
HSPA1A	inhibits	gene	0.60
FGF1	interacts_with	gene	0.60
PRDX1	activates	gene	0.60
P38	activates	gene	0.60
AKT	activates	gene	0.60
MTOR	therapeutic_target	gene	0.60
RCAN1	activates	gene	0.60
TNF	activates	gene	0.60
PI3K	activates	gene	0.60
PP2A	activates	gene	0.60
BRAF	activates	gene	0.60
SOD2	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
SOD3	inhibits	gene	0.60
P38	regulates	gene	0.60
EGFR	regulates	gene	0.60
ERK2	activates	gene	0.60
ATF4	activates	gene	0.60
TFAM	activates	gene	0.60
BCL2	activates	gene	0.60
BAX	activates	gene	0.60
BAX	regulates	gene	0.60
MTOR	activates	gene	0.60
TNF	associated_with	gene	0.60
EGF	activates	gene	0.60
MAPK3	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
NLRP3	activates	gene	0.60
ULK1	associated_with	gene	0.60
BTRC	associated_with	gene	0.60
FYN	associated_with	gene	0.60
ERK2	regulates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
CYLD	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
VEGF	inhibits	gene	0.60
SPR	therapeutic_target	gene	0.60
SRC	activates	gene	0.60
STAT3	activates	gene	0.60
JAK2	regulates	gene	0.60
STAT3	regulates	gene	0.60
E2F1	regulates	gene	0.60
MYC	regulates	gene	0.60
DIABLO	regulates	gene	0.60
TAU	activates	gene	0.60
MYC	activates	gene	0.60
AKT	regulates	gene	0.60
AKT1	regulates	gene	0.60
MAPK3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ERK1

Understanding Entity Pages

Summary

Wiki Pages (21)

ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1

neuroinflammation

NTF4 Protein

ncam2

Vitamin D Signaling Pathway in Neurodegeneration

nf1-protein

IGF-1 Signaling Pathway in Neurodegeneration

Thyroid Hormone Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

substance-p-nk1-signaling-neurodegeneration

tau-hyperphosphorylation

RASGRP1 Gene

Advanced Glycation End Products in Neurodegeneration

Orexin Neurons

vegfr-signaling-neurodegeneration

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Excitotoxicity Pathway

Neuroinflammation in Parkinson's Disease

Remyelination in Neurodegeneration