Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GNA11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GNA11 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | GNA11 |
| Full Name | G Protein Subunit Alpha 11 |
| Chromosome | 19q13.42 |
| Function | Gα₁₁ functions as a molecular switch, cycling between an inactive GDP-bound state and an active GTP-bound state upon GPCR activation. |
| Primary Expression | many tissues, with particularly high levels in: - Brain: Cortex, hippocampus, basal ganglia, cerebellum - Endocrine gla |
| Amino Acids | 354 aa |
| Pathways | Akt, Pi3K |
| UniProt ID | [P30678](https://www.uniprot.org/uniprot/P30678) |
| Ensembl ID | ENSG00000127955 |
| GeneCards | GNA11 |
| Human Protein Atlas | GNA11 |
| PLCβ activation | Hydrolysis of PIP₂ to IP₃ and DAG |
| Calcium release | IP₃-mediated calcium release from ER stores |
| PKC activation | DAG-dependent protein kinase C activation |
| Downstream effects | Modulation of ion channels, transcription factors, and cytoskeletal proteins |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, BRAF, PI3K, ERK1, GNAQ, STX17 |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GNA11["<b>GNA11</b>"]
Als{"Als"}
GNA11 -->|"activates"| Als
Ms{"Ms"}
GNA11 -->|"activates"| Ms
AKT["AKT"]
GNA11 -->|"activates"| AKT
Akt(["Akt"])
GNA11 -->|"activates"| Akt
Pi3K(["Pi3K"])
GNA11 -->|"activates"| Pi3K
neurodegeneration["neurodegeneration"]
GNA11 -->|"implicated in"| neurodegeneration
BRAF["BRAF"]
BRAF -->|"activates"| GNA11
KRAS["KRAS"]
KRAS -->|"activates"| GNA11
ERK["ERK"]
ERK -->|"activates"| GNA11
PI3K["PI3K"]
PI3K -->|"activates"| GNA11
GENES["GENES"]
GENES -->|"activates"| GNA11
ERK1["ERK1"]
ERK1 -->|"activates"| GNA11
GNAQ["GNAQ"]
GNAQ -->|"activates"| GNA11
STX17["STX17"]
STX17 -->|"activates"| GNA11
style GNA11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||