gene

BANG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BANG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

Summary

Page for BANG — BAG3 (Bcl-2-Associated Athanogene 3)

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🧬 Gene Info

Gene Symbol	BAG3
Full Name	BCL-2-Associated Athanogene 3
Chromosome	10q25.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	57.5 kDa
Amino Acids	575 aa
Exons	4
Pathways	Autophagy, Complement, Nf-Κb
GeneCards	BAG3
Human Protein Atlas	BAG3
Protein Quality Control	BAG3 helps maintain proteostasis by targeting misfolded proteins for degradation.
Cytoskeletal Organization	BAG3 interacts with the cytoskeleton, particularly Z-discs in muscle cells, where it helps maintain sarcomere integrity.
Anti-Apoptotic Signaling	Through interactions with Hsp70 and other proteins, BAG3 inhibits apoptosis.
Associated Diseases	ALS, ALZHEIMERS_DISEASE, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Astrocyte Phagocytosis
Known Drugs/Compounds	rapamycin
Interactions	ATG10, CLOCK, ATG12, HSPB8, BMAL1, STUB1
KG Connections	413 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BANG["BANG"]
    BANG -->|"regulates"| Cancer["Cancer"]
    BANG -->|"regulates"| Ms["Ms"]
    BANG -->|"regulates"| Cardiac["Cardiac"]
    BANG -->|"activates"| Als["Als"]
    BANG -->|"activates"| Inflammation["Inflammation"]
    BANG -->|"activates"| Parkinson["Parkinson"]
    BANG -->|"activates"| Stroke["Stroke"]
    BANG -->|"activates"| ALS["ALS"]
    DNA["DNA"] -->|"regulates"| BANG
    BMAL1["BMAL1"] -->|"regulates"| BANG
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| BANG
    STROKE["STROKE"] -->|"activates"| BANG
    EGR1["EGR1"] -->|"regulates"| BANG
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| BANG
    ATF3["ATF3"] -->|"regulates"| BANG
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| BANG
    AND["AND"] -->|"regulates"| BANG
    MICROGLIA["MICROGLIA"] -->|"activates"| BANG

Outgoing (71)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Pain	regulates	disease	0.65
Als	regulates	disease	0.65
BMAL1	regulates	gene	0.60
GPR37	activates	gene	0.60
PPARG	regulates	gene	0.60
NR3C1	regulates	gene	0.60
CEBPA	regulates	gene	0.60
NFKB1	regulates	gene	0.60
STAT3	regulates	gene	0.60
TNF	regulates	gene	0.60
ESR1	regulates	gene	0.60
GATA2	regulates	gene	0.60
ATF3	regulates	gene	0.60
EGR1	regulates	gene	0.60
Rb	regulates	protein	0.60
Nfkb	regulates	protein	0.60
Circadian Rhythm	regulates	pathway	0.60
Phagocytosis	activates	pathway	0.60
Calcium Signaling	activates	pathway	0.60
DNA	regulates	gene	0.60
AREG	regulates	gene	0.60
CANCER	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
PARKINSON	activates	gene	0.60
CANCER	activates	gene	0.60
Myelination	activates	pathway	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
HIF2A	regulates	gene	0.60
STROKE	activates	gene	0.60
Cholesterol	regulates	pathway	0.60
AND	regulates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60

Incoming (31)

Source	Relation	Type	Str
BMAL1	regulates	gene	0.60
EGR1	regulates	gene	0.60
ATF3	regulates	gene	0.60
GATA2	regulates	gene	0.60
TNF	regulates	gene	0.60
STAT3	regulates	gene	0.60
PPARG	regulates	gene	0.60
ESR1	regulates	gene	0.60
NFKB1	regulates	gene	0.60
NR3C1	regulates	gene	0.60
CEBPA	regulates	gene	0.60
DNA	regulates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
STROKE	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GENES	regulates	gene	0.60
AREG	regulates	gene	0.60
CANCER	regulates	gene	0.60
HIF2A	regulates	gene	0.60
AND	regulates	gene	0.60
INS	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BANG

Understanding Entity Pages

Summary

Wiki Pages (11)

BANG — BAG3 (Bcl-2-Associated Athanogene 3)

nfkb-neurodegeneration

Glycogen Synthase Kinase-3β (GSK-3β)

Investigating Complex Neurodegenerative Disorders (NCT03225144)

p70S6K/mTORC1 Signaling Pathway in Neurodegeneration

cGAS-STING Inhibitor Therapy for Neurodegeneration

Respiratory Dysfunction in Corticobasal Syndrome

STING Inhibitor Therapy in Neurodegeneration

DUSP2 Gene