| Gene Symbol | LYNPROTEIN |
| Chromosome | 8q13.1. |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | hematopoietic cells (B lymphocytes, myeloid cells, mast cells) and in microglia, where it serves as both a |
| Subcellular Localization | ** | Plasma membrane, Cytoplasm, Endosomes | |
| Molecular Weight | 56 kDa |
| Amino Acids | 21 aa |
| GeneCards | LYNPROTEIN |
| Human Protein Atlas | LYNPROTEIN |
| Unique domain (residues 1-65) | Lyn-specific sequences that determine substrate specificity; contains binding sites for immune receptors |
| SH3 domain (residues 68-125) | Binds proline-rich sequences; autoinhibitory function |
| SH2 domain (residues 130-205) | Phosphotyrosine binding; regulatory interactions |
| C-terminal tail | Tyr508 (human) phosphorylation by CSK maintains autoinhibition |
| B cell receptor (BCR) signaling | Phosphorylates ITAM motifs on Ig-α/Ig-β, initiating BCR signaling cascades |
| Associated Diseases | cancer |
| Interactions | ADRB2, AKT, AMPK, CD36, ERK1, FYN |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!