gene

ADRB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADRB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ADRB2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with Aging, Als, Alzheimer. Connected to 90 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ADRB2
Full Name	Beta-2 Adrenergic Receptor
Chromosome	5q31-q32
Function	encodes a 413-amino acid protein.
Amino Acids	4477 aa
Exons	4
UniProt ID	P07550
NCBI Gene ID	154
Ensembl ID	ENSG00000169252
OMIM	109630
GeneCards	ADRB2
Human Protein Atlas	ADRB2
TATA box	Core promoter element
CRE elements	cAMP response elements for regulated expression
AP-1 sites	Responsive to growth factors and cytokines
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
Interactions	GSK3B, LYN, MUL1, PSEN1, Rb, APP
KG Connections	149 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ADRB2 — AlphaFold P07550 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ADRB2["ADRB2"] -->|"associated"| Alzheimer["Alzheimer"]
    ADRB2["ADRB2"] -->|"therapeutic target"| Dementia["Dementia"]
    ADRB2["ADRB2"] -->|"associated"| Depression["Depression"]
    ADRB2["ADRB2"] -->|"associated"| Anxiety["Anxiety"]
    ADRB2["ADRB2"] -->|"associated"| Dementia_1["Dementia"]
    ADRB2["ADRB2"] -->|"therapeutic target"| Heart_Failure["Heart Failure"]
    MAOB["MAOB"] -->|"associated"| ADRB2["ADRB2"]
    GABRA1["GABRA1"] -->|"associated"| ADRB2["ADRB2"]
    CHAT["CHAT"] -->|"associated"| ADRB2["ADRB2"]
    CYP2D6["CYP2D6"] -->|"associated"| ADRB2["ADRB2"]
    style ADRB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (97)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Obesity	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
Als	protects_against	disease	0.65
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
MAOB	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
ATG5	therapeutic_target	gene	0.60
GSK3B	interacts_with	gene	0.60
LYN	interacts_with	gene	0.60
MUL1	inhibits	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
GAIN	causes	gene	0.60
Rb	associated_with	protein	0.60
Rb	inhibits	protein	0.60
APP	activates	gene	0.60
NGF	activates	gene	0.60
cancer	activates	disease	0.60
CYP2C19	associated_with	gene	0.60
MTHFR	associated_with	gene	0.60

Incoming (52)

Source	Relation	Type	Str
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
MAPK3	therapeutic_target	gene	0.60
BECLIN1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
P62	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
HMOX1	therapeutic_target	gene	0.60
FYN	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60
APP	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
PSEN1	inhibits	gene	0.60
LC3B	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
CYP1A2	associated_with	gene	0.60
DIABETES MELLITUS	causes	gene	0.60
CYP3A5	associated_with	gene	0.60
AMPK	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ADRB2

Understanding Entity Pages

Summary

Wiki Pages (15)

ADRB2 Gene

ADCY3 — Adenylate Cyclase 3

Beta-2 Adrenergic Receptor Neurons

A2 Noradrenergic Neurons

NBEA — Neurobeachin

Technical Architecture

The Five Layers

slc30a8

Beta-2 Adrenergic Receptor Protein

LYN Gene

Dorsal Raphe Serotonin in Depression

CYP3A4 — Cytochrome P450 3A4

Elucidata Polly (Multi-Omics Data Platform)