| Gene Symbol | MECP2PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | post-mitotic neurons |
| Subcellular Localization | </th><td>Nucleus</td></tr> |
| GeneCards | MECP2PROTEIN |
| Human Protein Atlas | MECP2PROTEIN |
| Methyl-CpG binding domain (MBD) | Residues 78-162, binds methylated DNA |
| Transcriptional repression domain (TRD) | Residues 207-310 |
| N-terminal domain | Involved in protein interactions |
| C-terminal domain | Contains a transcriptional repressor domain |
| Primary cause | MECP2 loss-of-function mutations cause 95% of Rett syndrome cases |
| Phenotype | Severe neurodevelopmental disorder with regression |
| Associated Diseases | Als, Autism, epilepsy, Rett syndrome |
| Interactions | Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND |
| KG Connections | 235 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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