| Gene Symbol | NCSTN |
| Aliases | NICASTRIN |
| Chromosome | 1p31.3 |
| Protein Family | Pen-2 family (γ-secretase complex) |
| Function | Complex Assembly: Nicastrin acts as a scaffold for γ-secretase complex assembly in the ER |
| Primary Expression | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Subcellular Localization | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Molecular Weight | 79 kDa |
| Amino Acids | 709 aa |
| Exons | 21 |
| Pathways | NF-κB |
| UniProt ID | Q92673 |
| GeneCards | NCSTN |
| Human Protein Atlas | NCSTN |
| Gene | NCSTN |
| Associated Diseases | ALS, Alzheimer, Neurodegeneration |
| Interactions | APP, AMYLOID, ALZHEIMER, PRESENILIN, NOTCH, PEN-2 |
| KG Connections | 78 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |