| Gene Symbol | NICASTRIN |
| Full Name | Nicastrin |
| Aliases | NTC, NCT, RP4-750H17.3, BPT, IGDCC3 |
| Chromosome | 1p31.3 |
| Protein Family | Pen-2 family (γ-secretase complex) |
| Function | Complex Assembly: Nicastrin acts as a scaffold for γ-secretase complex assembly in the ER |
| Primary Expression | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Subcellular Localization | Endoplasmic reticulum, Golgi apparatus, cell membrane |
| Molecular Weight | ~79 kDa |
| Amino Acids | 709 aa |
| Exons | 21 |
| Pathways | NF-κB |
| UniProt ID | Q9UKJ5 |
| NCBI Gene ID | 55620 |
| Ensembl ID | ENSG00000162736 |
| OMIM | 605352 |
| GeneCards | NICASTRIN |
| Human Protein Atlas | NICASTRIN |
| Associated Diseases | ALS, Alzheimer, Neurodegeneration |
| Interactions | APP, AMYLOID, ALZHEIMER, PRESENILIN, NOTCH, PEN-2 |
| KG Connections | 78 knowledge graph edges |
| Databases | GeneCardsHPASTRING |