protein 635 words KG: NPAS2PROTEIN
Contents

NPAS2 Protein

🔬 Protein Info
Gene SymbolNPAS2
Full NameNeuronal PAS Domain Protein 2
Chromosome2q22.1
FunctionThe NPAS2 gene encodes Neuronal PAS Domain Protein 2, a transcription factor that serves as a core component of the mammalian circadian clock.
Subcellular Localization</strong></td><td>Nucleus</td></tr>
Molecular Weight87 kDa
PathwaysCBFs
UniProt IDQ8BZD0
NCBI Gene ID10327
Ensembl IDENSG00000107077
OMIM605504
GeneCardsNPAS2
Human Protein AtlasNPAS2
Basic regionContacts E-box DNA sequences
Helix-loop-helixDimerization interface
Associated DiseasesFreezing Tolerance
InteractionsBMAL1, MTNR1A, MTNR1B, PER1, PER2
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (10)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Circadian Clock-Autophagy Synchronization
Score: 0.76
Purinergic Signaling Polarization Control
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (8)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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