Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PER1 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 59 entities in the SciDEX knowledge graph.
| Gene Symbol | PER1 |
| Chromosome | 17p13.1 |
| Function | PER1 (Period Circadian Regulator 1) is a core component of the mammalian circadian clock. |
| Molecular Weight | 136 kDa |
| Pathways | Amyloid, Mtor, Pi3K/Akt, circadian regulation |
| UniProt ID | O15055 |
| NCBI Gene ID | 5441 |
| Ensembl ID | ENSG00000132359 |
| OMIM | 602260 |
| GeneCards | PER1 |
| Human Protein Atlas | PER1 |
| Gene Name | Period Circadian Regulator 1 |
| Categories | Circadian Rhythm, Transcriptional Regulation, Cell Cycle |
| Associated Diseases | ALS, autism spectrum disorder |
| Known Drugs/Compounds | lithium |
| Interactions | FMR1, P38, TAU, PER2, AKT, AND |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PER1["<b>PER1</b>"]
Als{"Als"}
PER1 -->|"therapeutic target"| Als
Ms{"Ms"}
PER1 -->|"interacts with"| Ms
PER1 -->|"regulates"| Als
PER1 -->|"regulates"| Ms
PER1 -->|"expressed in"| Ms
Carcinoma{"Carcinoma"}
PER1 -->|"expressed in"| Carcinoma
Cancer{"Cancer"}
PER1 -->|"expressed in"| Cancer
Tumor{"Tumor"}
PER1 -->|"expressed in"| Tumor
PER1 -->|"expressed in"| Als
Schizophrenia{"Schizophrenia"}
PER1 -->|"regulates"| Schizophrenia
Circadian_Rhythm(["Circadian Rhythm"])
PER1 -->|"therapeutic target"| Circadian_Rhythm
GENES["GENES"]
PER1 -->|"regulates"| GENES
CRY1["CRY1"]
CRY1 -->|"interacts with"| PER1
BMAL1["BMAL1"]
BMAL1 -->|"interacts with"| PER1
CLOCK["CLOCK"]
CLOCK -->|"interacts with"| PER1
CLOCK -->|"associated with"| PER1
BMAL1 -->|"associated with"| PER1
PER3["PER3"]
PER3 -->|"expressed in"| PER1
PER3 -->|"associated with"| PER1
style PER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| circadian regulation | participates_in | pathway | 0.75 |
| AKT | expressed_in | gene | 0.70 |
| PER2 | expressed_in | gene | 0.70 |
| CLOCK | expressed_in | gene | 0.70 |
| BMAL1 | expressed_in | gene | 0.70 |
| CRY1 | expressed_in | gene | 0.70 |
| CRY2 | expressed_in | gene | 0.70 |
| Circadian Rhythm | expressed_in | pathway | 0.70 |
| apoptosis pathway | participates_in | pathway | 0.70 |
| REV | regulates | gene | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| Sleep Disorder | expressed_in | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Schizophrenia | regulates | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| Autism | expressed_in | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Autism | inhibits | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| CLOCK | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| SIRT1 | expressed_in | gene | 0.60 |
| CRY1 | associated_with | gene | 0.60 |
| NPAS2 | associated_with | gene | 0.60 |
| CRY2 | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| CRY1 | regulates | gene | 0.60 |
| CRY2 | regulates | gene | 0.60 |
| PER2 | regulates | gene | 0.60 |
| CLOCK | regulates | gene | 0.60 |
| BMAL1 | regulates | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| FMR1 | inhibits | gene | 0.60 |
| P38 | inhibits | gene | 0.60 |
| TAU | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BMAL1 | activates | gene | 0.65 |
| CLOCK | activates | gene | 0.65 |
| CRY1 | activates | gene | 0.65 |
| CRY1 | interacts_with | gene | 0.60 |
| BMAL1 | interacts_with | gene | 0.60 |
| CLOCK | interacts_with | gene | 0.60 |
| CLOCK | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| PER3 | expressed_in | gene | 0.60 |
| PER3 | associated_with | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| CRY2 | expressed_in | gene | 0.60 |
| CLOCK | expressed_in | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| BMAL1 | expressed_in | gene | 0.60 |
| NPAS2 | associated_with | gene | 0.60 |
| MTNR1A | associated_with | gene | 0.60 |
| PER2 | associated_with | gene | 0.60 |
| TAU | inhibits | gene | 0.60 |
| ARNTL | expressed_in | gene | 0.60 |
| MTNR1B | associated_with | gene | 0.60 |
| FMR1 | inhibits | gene | 0.60 |
| NR1D1 | expressed_in | gene | 0.60 |
| MTNR1B | interacts_with | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| lithium | targets | drug | 0.60 |
| ARNT | regulates | gene | 0.60 |
| ARNTL | regulates | gene | 0.60 |
| NR1D1 | regulates | gene | 0.60 |
| CRY2 | interacts_with | gene | 0.60 |
| AMYLOID-BETA | expressed_in | gene | 0.60 |
| APP/PS1 | expressed_in | gene | 0.60 |
| AMYLOID | expressed_in | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| CLOCK GENE | expressed_in | gene | 0.60 |
| CIRCADIAN RHYTHM | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| MAPK | inhibits | gene | 0.60 |
| BMAL1 | regulates | gene | 0.55 |
| CLOCK | regulates | gene | 0.55 |
| CRY1 | expressed_in | gene | 0.55 |
| CRY2 | activates | gene | 0.55 |
| HDAC3 | activates | gene | 0.55 |
| MTNR1A | interacts_with | gene | 0.50 |
| NPAS2 | interacts_with | gene | 0.50 |
| ARNTL | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||