protein

PER1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

PER1 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, associated with. Associated with Als, Alzheimer, Cancer. Connected to 59 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPER1
Chromosome17p13.1
FunctionPER1 (Period Circadian Regulator 1) is a core component of the mammalian circadian clock.
Molecular Weight136 kDa
PathwaysAmyloid, Mtor, Pi3K/Akt, circadian regulation
UniProt IDO15055
NCBI Gene ID5441
Ensembl IDENSG00000132359
OMIM602260
GeneCardsPER1
Human Protein AtlasPER1
Gene NamePeriod Circadian Regulator 1
CategoriesCircadian Rhythm, Transcriptional Regulation, Cell Cycle
Associated DiseasesALS, autism spectrum disorder
Known Drugs/Compoundslithium
InteractionsFMR1, P38, TAU, PER2, AKT, AND
KG Connections148 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PER1 — AlphaFold O15055 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

PER1 Gene

gene · 604 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

Circadian Rhythm in Neurodegeneration

mechanism · 4939 words

Circadian Rhythm Modulation Therapy

therapeutic · 3566 words

Sleep and Neurodegeneration

mechanism · 3566 words

Sleep-Wake Cycle

mechanism · 3410 words

Pathway Diagram

graph TD
    PER1["<b>PER1</b>"]
    Als{"Als"}
    PER1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    PER1 -->|"interacts with"| Ms
    PER1 -->|"regulates"| Als
    PER1 -->|"regulates"| Ms
    PER1 -->|"expressed in"| Ms
    Carcinoma{"Carcinoma"}
    PER1 -->|"expressed in"| Carcinoma
    Cancer{"Cancer"}
    PER1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    PER1 -->|"expressed in"| Tumor
    PER1 -->|"expressed in"| Als
    Schizophrenia{"Schizophrenia"}
    PER1 -->|"regulates"| Schizophrenia
    Circadian_Rhythm(["Circadian Rhythm"])
    PER1 -->|"therapeutic target"| Circadian_Rhythm
    GENES["GENES"]
    PER1 -->|"regulates"| GENES
    CRY1["CRY1"]
    CRY1 -->|"interacts with"| PER1
    BMAL1["BMAL1"]
    BMAL1 -->|"interacts with"| PER1
    CLOCK["CLOCK"]
    CLOCK -->|"interacts with"| PER1
    CLOCK -->|"associated with"| PER1
    BMAL1 -->|"associated with"| PER1
    PER3["PER3"]
    PER3 -->|"expressed in"| PER1
    PER3 -->|"associated with"| PER1
    style PER1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (95)

TargetRelationTypeStr
circadian regulationparticipates_inpathway0.75
AKTexpressed_ingene0.70
PER2expressed_ingene0.70
CLOCKexpressed_ingene0.70
BMAL1expressed_ingene0.70

Incoming (53)

SourceRelationTypeStr
BMAL1activatesgene0.65
CLOCKactivatesgene0.65
CRY1activatesgene0.65
CRY1interacts_withgene0.60
BMAL1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found