concept

MTNR1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTNR1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

No summary available yet. View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MTNR1B
Key Genes/Proteins	ABCB1, ADRA2A, ALZHEIMER, ALZHEIMER DISEASE, AND, ANXIETY
Related Diseases	Als, ALS, Alzheimer, anxiety, Anxiety

Wiki Pages (1)

Knowledge base pages for this entity

MT1B (MTNR1B) Receptor Neurons

cell · 856 words

→

Pathway Diagram

graph TD
    MTNR1B["MTNR1B"]
    MTNR1B -->|"implicated in"| neurodegeneration["neurodegeneration"]
    MTNR1B -->|"expressed in"| PBMC["PBMC"]
    MTNR1B -->|"regulates"| Sleep["Sleep"]
    MTNR1B -->|"involved_in"| Anxiety["Anxiety"]
    MTNR1B -->|"involved_in"| Glioma["Glioma"]
    MTNR1B -->|"expressed in"| Astrocytes["Astrocytes"]
    MTNR1B -->|"interacts"| LRP1["LRP1"]
    h_7e0b5ade["h-7e0b5ade"] -->|"targets"| MTNR1B
    LRP1 -->|"interacts"| MTNR1B
    MTNR1A["MTNR1A"] -->|"interacts"| MTNR1B
    Melatonin_for_Tauopathy__Compr["Melatonin for Tauopathy: Comprehensive Evidence Synthesis"] -->|"references"| MTNR1B

Outgoing (113)

Target	Relation	Type	Str
circadian rhythms	regulates	process	0.90
NMDA receptor	associated_with	receptor	0.90
Insomnia	therapeutic_target	disease	0.90
parvalbumin-positive interneurons	activates	cell_type	0.85
Schizophrenia	therapeutic_target	disease	0.85
prefrontal cortex inhibitory tone	associated_with	process	0.80
DEPRESSION	biomarker_for	disease	0.70
neurodegeneration	associated_with	disease	0.65
Sleep Disorder	expressed_in	disease	0.65
Sleep Disorder	contributes_to	disease	0.65
Bipolar	methylates	disease	0.65
Diabetes	encodes	disease	0.65
Anxiety	encodes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
circadian regulation	participates_in	pathway	0.65
Als	associated_with	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Bipolar	regulates	disease	0.65
Anxiety	associated_with	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Depression	activates	disease	0.65
Als	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Depression	contributes_to	disease	0.65
Diabetes	contributes_to	disease	0.65
Cancer	activates	disease	0.65
Glioblastoma	activates	disease	0.65
depression	methylates	disease	0.60
diabetes	associated_with	disease	0.60
glioblastoma	expressed_in	disease	0.60
autism	associated_with	disease	0.60
anxiety	associated_with	disease	0.60
GLIOBLASTOMA	activates	gene	0.60
cortex	expressed_in	brain_region	0.60
depression	promotes	disease	0.60
ANXIETY	associated_with	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
NPAS2	interacts_with	gene	0.60
PER1	interacts_with	gene	0.60
PER2	interacts_with	gene	0.60
NR1D1	associated_with	gene	0.60
PER3	associated_with	gene	0.60
MULTIPLE SCLEROSIS	has_variant	disease	0.60
CLOCK	expressed_in	gene	0.60
MTNR1A	activates	gene	0.60
MTNR1A	expressed_in	gene	0.60
MTNR1A	associated_with	gene	0.60

Incoming (73)

Source	Relation	Type	Str
Ucm924	activates	drug	0.90
h-7e0b5ade	targets_gene	hypothesis	0.90
MTNR1A	co_mentioned_with	gene	0.80
h-7e0b5ade	targets	hypothesis	0.80
MT1	expressed_in	gene	0.60
HTR1A	targets	gene	0.60
MTNR1A	targets	gene	0.60
TCF7L2	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1A	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
DEPRESSION	contributes_to	gene	0.60
ADRA2A	associated_with	gene	0.60
NPAS2	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
PER2	associated_with	gene	0.60
PER3	expressed_in	gene	0.60
PER1	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1A	methylates	gene	0.60
MTNR1A	promotes	gene	0.60
GABRA1	associated_with	gene	0.60
GENES	activates	gene	0.60
SLEEP-WAKE CYCLE	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	regulates	gene	0.60
GENES	expressed_in	gene	0.60
AND	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
ALZHEIMER DISEASE	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
TPH2	associated_with	gene	0.60
MTNR1A	binds_to	gene	0.60
GABRB2	targets	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ANXIETY	encodes	gene	0.60
MTNR1A	inhibits	gene	0.60
GABRA1	targets	gene	0.60
DNA	expressed_in	gene	0.60
BMAL1	activates	gene	0.55
MTNR1A	regulates	gene	0.55
CLOCK	activates	gene	0.55
LRP1	interacts_with	gene	0.53
MTNR1A	interacts_with	gene	0.53
TPH2	interacts_with	gene	0.50
NPAS2	interacts_with	gene	0.50
PER1	interacts_with	protein	0.50
PER2	interacts_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Anti-amyloid antibodies (lecanemab, donanemab) have ~0.1% brain penetrance. Engi

closed · Rounds: 4 · Score: 0.91 · 2026-04-06