protein

PER2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PER2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

202Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PER2 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, activates. Associated with Als, Alzheimer, Autism. Connected to 106 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PER2
Chromosome	2p13
Function	PER2 is a core clock gene essential for circadian rhythm generation.
Molecular Weight	180 kDa
Pathways	Akt, Circadian Rhythm, Lipid Metabolism, Mtor, Pi3K
UniProt ID	Q8BZD0
NCBI Gene ID	8864
Ensembl ID	ENSG00000132266
OMIM	603714
GeneCards	PER2
Human Protein Atlas	PER2
Gene Name	Period Circadian Regulator 2
Categories	Circadian Rhythm, Transcriptional Regulation, Sleep Biology
Associated Diseases	ALS, Ms, autism spectrum disorder
Interactions	CLOCK, BMAL1, NR1D1, HSP70, ATF3, DLAT
KG Connections	202 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PER2 — AlphaFold Q8BZD0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PER2["PER2"]
    PER2 -->|"regulates"| Als["Als"]
    PER2 -->|"activates"| Ms["Ms"]
    PER2 -->|"regulates"| Autism["Autism"]
    PER2 -->|"expressed in"| Carcinoma["Carcinoma"]
    PER2 -->|"expressed in"| Cancer["Cancer"]
    PER2 -->|"expressed in"| Tumor["Tumor"]
    CRY1["CRY1"] -->|"interacts"| PER2
    BMAL1["BMAL1"] -->|"interacts"| PER2
    CLOCK["CLOCK"] -->|"interacts"| PER2
    GENES["GENES"] -->|"regulates"| PER2
    PER1["PER1"] -->|"expressed in"| PER2
    AKT["AKT"] -->|"expressed in"| PER2
    MTOR["MTOR"] -->|"regulates"| PER2
    FASN["FASN"] -->|"regulates"| PER2

Outgoing (112)

Target	Relation	Type	Str
NF-κB	inhibits	pathway	0.95
PD-L1	inhibits	protein	0.95
HSP90	binds_to	protein	0.92
oral squamous cell carcinoma	protects_against	disease	0.88
IKK	promotes	protein	0.88
Circadian Rhythm	expressed_in	pathway	0.80
circadian regulation	participates_in	pathway	0.75
Sleep Disorder	expressed_in	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Autism	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	activates	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
Alzheimer	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
CLOCK	expressed_in	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	activates	gene	0.60
BMAL1	activates	gene	0.60
SIRT1	regulates	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	regulates	gene	0.60
ARNT	regulates	gene	0.60
CLOCK	inhibits	gene	0.60
LPL	expressed_in	gene	0.60
SIRT1	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
NR1D1	activates	gene	0.60
NFKB1	expressed_in	gene	0.60
CLOCK	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
HSP70	activates	gene	0.60
ATF3	activates	gene	0.60

Incoming (90)

Source	Relation	Type	Str
h-de52344d	targets_gene	hypothesis	0.90
PER1	expressed_in	gene	0.70
CRY1	expressed_in	gene	0.70
CRY2	expressed_in	gene	0.70
CRY1	activates	gene	0.65
CRY1	interacts_with	gene	0.60
BMAL1	interacts_with	gene	0.60
CLOCK	interacts_with	gene	0.60
CLOCK	regulates	gene	0.60
BMAL1	regulates	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	regulates	gene	0.60
FASN	regulates	gene	0.60
CRY1	regulates	gene	0.60
AKT	regulates	gene	0.60
NAMPT	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
UBR5	inhibits	gene	0.60
FASN	expressed_in	gene	0.60
NFKBIA	expressed_in	gene	0.60
PGC1A	expressed_in	gene	0.60
PER3	expressed_in	gene	0.60
PER3	associated_with	gene	0.60
PER1	associated_with	gene	0.60
CRY1	associated_with	gene	0.60
NPAS2	associated_with	gene	0.60
CRY2	associated_with	gene	0.60
PER1	regulates	gene	0.60
CRY2	regulates	gene	0.60
AKT	activates	gene	0.60
SLC31A1	activates	gene	0.60
CLOCK	activates	gene	0.60
BMAL1	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
GFAP	activates	gene	0.60
BDNF	expressed_in	gene	0.60
ARNT	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
REST	expressed_in	gene	0.60
ATXN3	activates	gene	0.60
BMAL1	activates	gene	0.60
APP	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
MTNR1A	associated_with	gene	0.60
ARNTL	expressed_in	gene	0.60
MTNR1B	associated_with	gene	0.60
NR1D1	expressed_in	gene	0.60
MTNR1B	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PER2

Understanding Entity Pages

Summary

Wiki Pages (21)

PER2 Gene

Sleep and Circadian Dysfunction in Alzheimer's Disease

Circadian Rhythm in Neurodegeneration

Circadian Rhythm Modulation Therapy

Sleep and Neurodegeneration

Sleep-Wake Cycle

Sleep Disruption in Alzheimer's Disease

Circadian Dysfunction Across Neurodegenerative Diseases

Sleep Architecture Changes in CBS and PSP

Circadian Rhythm Dysfunction in Alzheimer's Disease

sleep-disruption-neurodegeneration

Circadian Disruption in Neurodegeneration

Circadian Rhythm Disruption in Neurodegeneration

GSK3-beta Protein

Circadian Rhythm Dysfunction in Corticobasal Syndrome

CSNK1D - Casein Kinase 1 Delta

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease