gene 1,499 words KG: NPAS4 2026-03-28
kind:genesection:genesstate:published
Contents

NPAS4 Gene

🧬 Gene Info
Gene SymbolNPAS4
Full NameNeuronal PAS domain protein 4
Chromosome19q13.3
Protein FamilybHLH-PAS transcription factor family
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight102 kDa
Amino Acids892 aa
Exons9
PathwaysAutophagy, Notch
GeneCardsNPAS4
Human Protein AtlasNPAS4
bHLH domainN-terminal (50-100 aa)
PAS-A domain(150-250 aa)
PAS-B domain(300-400 aa)
Associated Diseasesneurodegeneration
InteractionsSTAT3, HDAC3, FOXP1, WAS, C-FOS, CHIP
KG Connections72 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (18)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: regulates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates
FOXP1 Gene
gene · KG edge: activates
FOS Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NPAS4 regulates APP
NPAS4 activates STAT3
NPAS4 activates HDAC3
NPAS4 expressed_in BDNF
NPAS4 activates FOXP1
NPAS4 regulates HDAC3
NPAS4 regulates DLG4
NPAS4 regulates GRIN2B
NPAS4 inhibits HDAC3
NPAS4 regulates NR2B