gene 1,025 words KG: PSD95 2026-03-24
kind:genesection:genesstate:published
Contents

DLG4 Gene

🧬 Gene Info
Gene SymbolPSD95
Full NameDLG4
Chromosome8p12 [@migaud1998]
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
PathwaysApoptosis, Astrocyte Reactivity, Dendritic Spine, Epigenetic, Long-Term Potentiation
UniProt IDP78352
NCBI Gene ID1749
Ensembl IDENSG00000132535
GeneCardsPSD95
Human Protein AtlasPSD95
Associated DiseasesALS, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsrapamycin, CN2097, SYN3
InteractionsKEAP1, NRF2, APOE, SYP, SNAP25, MTOR
KG Connections523 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59

Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (7)

Synaptic plasticity and protein expression analysis in mPFC
exploratory · proposed · Score: 0.85
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

PSD95 expressed_in BDNF
PSD95 associated_with LC3
PSD95 activates KEAP1
PSD95 activates NRF2
PSD95 activates APOE
PSD95 co_discussed TAU
PSD95 co_discussed SNAP25
PSD95 treats CXCR4
PSD95 treats MTOR
PSD95 treats CCR5