concept

EXCITOTOXICITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXCITOTOXICITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

291Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	EXCITOTOXICITY
Summary	# Excitotoxicity[1] ## Introduction Excitotoxicity is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function,
Key Genes/Proteins	ERK, GLUTAMATE_RECEPTORS, UBIQUITIN, AMPK
Related Diseases	CELL DEATH, SYNAPTIC PLASTICITY, GABA, NECROPTOSIS, FERROPTOSIS

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EXCITOTOXICITY["EXCITOTOXICITY"]
    EXCITOTOXICITY -->|"causes"| Neurotoxicity["Neurotoxicity"]
    EXCITOTOXICITY -->|"causes"| STIM1["STIM1"]
    EXCITOTOXICITY -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    EXCITOTOXICITY -->|"inhibits"| FOXO3["FOXO3"]
    EXCITOTOXICITY -->|"activates"| NEURON["NEURON"]
    EXCITOTOXICITY -->|"activates"| STING["STING"]
    EXCITOTOXICITY -->|"promotes"| HIPPOCAMPUS["HIPPOCAMPUS"]
    EXCITOTOXICITY -->|"promotes"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    EXCITOTOXICITY -->|"regulates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    glutamate_receptors["glutamate receptors"] -->|"causes"| EXCITOTOXICITY
    Glutamate["Glutamate"] -->|"causes"| EXCITOTOXICITY
    Glutamate_receptors["Glutamate receptors"] -->|"mediates"| EXCITOTOXICITY
    NAD_metabolism["NAD metabolism"] -->|"participates in"| EXCITOTOXICITY
    GLUTAMATE["GLUTAMATE"] -->|"causes"| EXCITOTOXICITY
    glutamate["glutamate"] -->|"causes"| EXCITOTOXICITY
    ginsenosides["ginsenosides"] -->|"inhibits"| EXCITOTOXICITY
    inflammation["inflammation"] -->|"causes"| EXCITOTOXICITY
    GLUTAMATE_RECEPTORS["GLUTAMATE_RECEPTORS"] -->|"causes"| EXCITOTOXICITY

Outgoing (131)

Target	Relation	Type	Str
CELL DEATH	activates	phenotype	0.70
ERK	regulates	gene	0.70
UBIQUITIN	degrades	protein	0.65
NECROPTOSIS	activates	phenotype	0.65
AMPK	activates	gene	0.65
FERROPTOSIS	activates	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
FERROPTOSIS	inhibits	phenotype	0.65
NECROPTOSIS	regulates	phenotype	0.65
AXONAL DEGENERATION	activates	phenotype	0.65
FERROPTOSIS	causes	phenotype	0.65
STIM1	causes	protein	0.64
SPINAL CORD	implicated_in	brain_region	0.55
PARKINSON'S DISEASE	participates_in	disease	0.55
GLUTAMATE	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
FOXO3	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
NEURON	regulates	cell_type	0.50
OXIDATIVE STRESS	implicated_in	process	0.50
NEURON	implicated_in	cell_type	0.50
PROTEIN AGGREGATION	associated_with	process	0.50
MITOCHONDRIAL DYSFUNCTION	associated_with	process	0.50
Proteins	inhibits	protein	0.50
CYTOKINE	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Cognitive Decline	associated_with	disease	0.50
Proteins	interacts_with	protein	0.50
CORTEX	associated_with	brain_region	0.50
RIVASTIGMINE	associated_with	drug	0.45
GALANTAMINE	associated_with	drug	0.45
DONEPEZIL	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
SPINAL CORD	associated_with	brain_region	0.45
TAU	co_discussed	protein	0.40
SLC7A11	co_discussed	gene	0.40
PARKINSON	co_discussed	disease	0.40
PARKINSON'S DISEASE	co_discussed	disease	0.40
SLC7A11	activates	gene	0.35
MITOCHONDRIAL DYSFUNCTION	interacts_with	process	0.35
NEUROTOXICITY	interacts_with	process	0.35
OXIDATIVE STRESS	associated_with	process	0.35
FERROPTOSIS	implicated_in	process	0.35
ISCHEMIA	associated_with	disease	0.35
NEURON	associated_with	cell_type	0.35
STROKE	associated_with	disease	0.35

Incoming (160)

Source	Relation	Type	Str
GLUTAMATE	causes	drug	0.72
SYNAPTIC PLASTICITY	causes	phenotype	0.70
GABA	protects_against	phenotype	0.70
GABA	inhibits	phenotype	0.70
GLUTAMATE_RECEPTORS	causes	protein	0.68
ALZHEIMER'S DISEASE	implicated_in	disease	0.65
ROS	inhibits	phenotype	0.65
BDNF	activates	gene	0.65
STROKE	causes	disease	0.65
LOCUS COERULEUS	causes	brain_region	0.65
KYNURENINE PATHWAY	activates	pathway	0.65
ASTROCYTE	causes	cell_type	0.65
ASTROCYTES	exacerbates	cell_type	0.65
ALZHEIMER'S DISEASE	activates	disease	0.58
AKT	activates	gene	0.58
GLUTAMATE	depleted_in	phenotype	0.55
GABA	expressed_in	phenotype	0.55
C9ORF72	co_discussed	entity	0.50
APOPTOSIS	implicated_in	process	0.50
ALZHEIMER	causes	disease	0.50
NEURODEGENERATION	causes	process	0.50
NEUROINFLAMMATION	causes	process	0.50
INFLAMMATION	associated_with	process	0.50
OXIDATIVE STRESS	associated_with	process	0.50
OXIDATIVE STRESS	activates	process	0.50
C9ORF72	activates	gene	0.50
NEURODEGENERATION	activates	process	0.50
SLC7A11	activates	gene	0.50
STING	activates	gene	0.50
OXIDATIVE STRESS	regulates	process	0.50
Neurodegeneration	inhibits	disease	0.50
C9ORF72	inhibits	gene	0.50
GLUTAMATE	inhibits	concept	0.50
FOXO3	activates	gene	0.50
GLUTAMATE	activates	concept	0.50
STIM1	activates	gene	0.50
oxidative stress	activates	phenotype	0.50
Hippocampus	activates	entity	0.50
oxidative stress	interacts_with	phenotype	0.50
NEUROTOXICITY	interacts_with	concept	0.50
Neuroinflammation	associated_with	process	0.50
oxidative stress	associated_with	phenotype	0.50
ferroptosis	associated_with	phenotype	0.50
CELL DEATH	associated_with	concept	0.50
apoptosis	activates	process	0.50
Neurodegeneration	associated_with	disease	0.50
amyotrophic lateral sclerosis	associated_with	gene	0.50
GLUTAMATE	associated_with	concept	0.50
Neuron	activates	cell_type	0.50
MOTOR NEURONS	activates	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EXCITOTOXICITY

Understanding Entity Pages

Wiki Pages (21)

Excitotoxicity

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Atypical Parkinsonism

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway