Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ABETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABETA |
| Pathways | Protein Assembly |
| GeneCards | ABETA |
| Human Protein Atlas | ABETA |
| Affiliations | University of California San Diego |
| Country | USA |
| H-index | 40 |
| Research Focus | Alzheimer's Disease |
| Mechanisms | Amyloid |
| Associated Diseases | Alzheimer's Disease |
| Interactions | NMDAR, AMPAR, Fyn, NR2B, GSK-3beta, CDK5 |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ABETA["ABETA"] -->|"causes"| Alzheimer_s_Disease["Alzheimer's Disease"]
style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"involved in"| Protein_Assembly["Protein Assembly"]
style Protein_Assembly fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"component of"| Extracellular_Deposits["Extracellular Deposits"]
style Extracellular_Deposits fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"biomarker for"| Lewy_Pathology["Lewy Pathology"]
style Lewy_Pathology fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"regulates"| CA2["CA2"]
style CA2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"co discussed"| TAU["TAU"]
style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
ABETA["ABETA"] -->|"co discussed"| ALZHEIMER["ALZHEIMER"]
style ALZHEIMER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
LEPTIN["LEPTIN"] -->|"regulates"| ABETA["ABETA"]
style LEPTIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
GD3_synthase["GD3 synthase"] -->|"interacts"| ABETA["ABETA"]
style GD3_synthase fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style ABETA fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | causes | disease | 0.95 |
| Protein Assembly | involved_in | process | 0.90 |
| Extracellular Deposits | component_of | phenotype | 0.90 |
| Lewy Pathology | biomarker_for | phenotype | 0.85 |
| synapse turnover | associated_with | process | 0.80 |
| NMDAR | activates | protein | 0.80 |
| AMPAR | inhibits | protein | 0.80 |
| PrPC | binds_to | protein | 0.80 |
| mGluR5 | binds_to | protein | 0.80 |
| Fyn | activates | protein | 0.80 |
| NR2B | activates | protein | 0.80 |
| GSK-3beta | activates | protein | 0.80 |
| CDK5 | activates | protein | 0.80 |
| TLR4 | activates | protein | 0.80 |
| TREM2 | activates | protein | 0.80 |
| IL-1beta | upregulates | protein | 0.80 |
| TNF-alpha | upregulates | protein | 0.80 |
| C1q | upregulates | protein | 0.80 |
| RNS | induces | compound | 0.80 |
| BDNF | inhibits | protein | 0.80 |
| TrkB | inhibits | protein | 0.80 |
| proBDNF | upregulates | protein | 0.80 |
| p75NTR | upregulates | protein | 0.80 |
| CREB | inhibits | protein | 0.80 |
| CA2 | regulates | protein | 0.64 |
| TAU | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| APP | co_discussed | entity | 0.50 |
| ASTROCYTE | co_discussed | entity | 0.50 |
| ASTROCYTES | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| LEPTIN | regulates | protein | 0.80 |
| GD3 synthase | interacts_with | gene | 0.80 |
| LEPTIN | inhibits | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroscience | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||