| Gene Symbol | NRXN3 |
| Protein Family | Neurexin family (NRXN1, NRXN2, NRXN3) |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cerebral cortex (layer 2/3 pyramidal neurons), hippocampus (CA1-CA3, dentate gyrus), striatum ( |
| Subcellular Localization | Presynaptic membrane, synaptic vesicles |
| Molecular Weight | ~180 kDa (alpha), ~160 kDa (beta) |
| Exons | 24 |
| Pathways | Oxidative Stress, Sod1 |
| UniProt ID | Q9UHD8 |
| GeneCards | NRXN3 |
| Human Protein Atlas | NRXN3 |
| Protein Name | Neurexin 3 |
| Brain Region | Expression Level |
| Cerebral [Cortex](/brain-regions/cortex) | High - layer 5 pyramidal neurons |
| [Hippocampus](/brain-regions/hippocampus) | Moderate-high - CA3 region |
| Associated Diseases | ALS, Alzheimer |
| Interactions | PDHA1, BDNF, PRKAA1, SOD1, NLGN2, CYCS |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |