gene

CAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1394Connections

21Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

CAT is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ADH, ALI. Connected to 740 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CAT
Full Name	Catalase
Chromosome	11
Protein Type	Enzyme
Function	Catalase is a tetrameric heme-containing enzyme that functions as one of the primary antioxidant defenses in cells.
Primary Expression	peroxisomes (primary location), cytosol and mitochondria, with highest levels in liver, kidney, and brain
Subcellular Localization	**: Peroxisomes
Pathways	Akt, Apoptosis, Autophagy, Epigenetic, Ferroptosis
UniProt ID	P04040
NCBI Gene ID	847
Ensembl ID	ENSG00000121691
OMIM	115500
GeneCards	CAT
Human Protein Atlas	CAT
Associated Diseases	AD, ADH, ALI, ALS, AMI, Aging
Known Drugs/Compounds	rapamycin
Interactions	OPTN, DNM1L, CANX, LGALS3, CALCOCO2, G3BP1
KG Connections	1394 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAT — AlphaFold P04040 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ROS["Reactive Oxygen Species"] -->|"generates"| H2O2["Hydrogen Peroxide"]
    CAT["Catalase"] -->|"detoxifies"| H2O2
    H2O2 -->|"damages"| SQSTM1["SQSTM1/p62"]
    CAT -->|"regulates"| SQSTM1
    SQSTM1 -->|"activates"| RPS6KB1["RPS6KB1/S6K1"]
    RPS6KB1 -->|"phosphorylates"| EIF4EBP1["EIF4EBP1"]
    SQSTM1 -->|"interacts"| RAB7A["RAB7A"]
    RAB7A -->|"regulates"| CTSD["CTSD/Cathepsin D"]
    H2O2 -->|"inhibits"| PPARGC1A["PPARGC1A/PGC-1alpha"]
    CAT -->|"protects"| PPARGC1A
    PPARGC1A -->|"activates"| SREBF1["SREBF1/SREBP1"]
    CTSD -->|"promotes"| Autophagy["Autophagy"]
    H2O2 -->|"causes"| Neurodegeneration["Neurodegeneration"]
    CAT -->|"prevents"| Neurodegeneration

Outgoing (962)

Target	Relation	Type	Str
Inflammation	inhibits	disease	0.85
neural stem cells	activates	cell_type	0.80
oxidative stress	protects_against	process	0.80
GSH	associated_with	gene	0.80
Oxidative Stress	associated_with	pathway	0.80
HO-1	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Oxidative Stress	inhibits	pathway	0.80
Als	interacts_with	disease	0.75
Als	inhibits	disease	0.75
Als	activates	disease	0.75
Als	regulates	disease	0.75
Inflammation	activates	disease	0.75
Cardiac	regulates	disease	0.75
Diabetes	interacts_with	disease	0.75
Senescence	regulates	disease	0.75
Alzheimer	activates	disease	0.75
Inflammation	causes	disease	0.75
oxidative stress	associated_with	process	0.75
SQSTM1	regulates	gene	0.70
PPARGC1A	regulates	gene	0.70
BCL2	associated_with	gene	0.70
NRF2	activates	gene	0.70
NRF2	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Autophagy	inhibits	pathway	0.70
Mtor	activates	pathway	0.70
BCL-2	activates	gene	0.70
IL-6	inhibits	gene	0.70
TNF-Α	inhibits	gene	0.70
Apoptosis	inhibits	pathway	0.70
AMPK	activates	gene	0.70
TNF-Α	implicated_in	gene	0.70
Oxidative Stress	causes	pathway	0.70
INFLAMMATION	inhibits	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
neural stem cells	regulates	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
TNF	causes	gene	0.65
Spinal Cord Injury	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65

Incoming (432)

Source	Relation	Type	Str
FOXO1	upregulates	gene	0.90
116B	upregulates	compound	0.85
ROS	inhibits	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
BAX	associated_with	gene	0.70
BAX	activates	gene	0.70
CYCS	inhibits	gene	0.70
TNF	inhibits	gene	0.70
TNF	implicated_in	gene	0.70
NQO1	activates	gene	0.70
KEAP1	associated_with	gene	0.70
APOPTOSIS	activates	gene	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
OXIDATIVE STRESS	causes	gene	0.70
APOPTOSIS	inhibits	gene	0.70
ATG	activates	gene	0.70
ATP	activates	gene	0.70
ATP	inhibits	gene	0.70
BDNF	expressed_in	gene	0.65
BDNF	causes	gene	0.65
ACTB	regulates	gene	0.60
PPARA	regulates	gene	0.60
SOD2	associated_with	gene	0.60
PIK3C3	regulates	gene	0.60
RPS6	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
MTOR	regulates	gene	0.60
CTSD	regulates	gene	0.60
LAMP1	regulates	gene	0.60
MYC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
PPARG	regulates	gene	0.60
RAB7A	regulates	gene	0.60
RUBCN	regulates	gene	0.60
EGFR	regulates	gene	0.60
SREBF1	regulates	gene	0.60
LRP2	regulates	gene	0.60
MFN1	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.674	neuroimmunology	What is the temporal sequence of TREM2 s
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.610	neurodegeneration	What molecular mechanism causes VCP muta
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran

TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis	0.575	neurodegeneration	What molecular mechanism causes VCP muta
TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.567	neuroinflammation	Why is TYROBP deficiency neuroprotective
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.557	neurodegeneration	Why does autophagy inhibition improve ne
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.512	neurodegeneration	What are the mechanisms by which gut mic
Heat Shock Protein 70 Disaggregase Amplification	0.511	neurodegeneration	TDP-43 phase separation therapeutics for
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri	0.503	neurodegeneration	Synaptic pruning by microglia in early A
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocyte-Microglia Communication Rebalancing via Cytokine M	0.490	neurodegeneration	Which cell types show the most significa
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.485	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Circadian-Gated Maresin Biosynthesis Amplification	0.471	neurodegeneration	Neuroinflammation resolution mechanisms
Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated A	0.461	neuroscience	Circuit-level neural dynamics in neurode
TREM2 Activation as an Amplification Node for R136S Protecti	0.459	neurodegeneration	What molecular mechanisms underlie the d
CaMKII-Dependent Synaptic Circuit Amplification	0.444	neuroscience	Circuit-level neural dynamics in neurode
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Quantum Coherence Disruption in Cellular Communication	0.336	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress [PMID:40066224]	Liu H, Zhou Y, Wang Z, Liu D, Li Y, Lai	MedComm (2020)	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in [PMID:37643058]	Ghosh S, Vashisth K, Ghosh S, Han SS, Bh	J Biomol Struct Dyn	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteom [PMID:37652020]	Yuan S, Xu F, Li X, Chen J, Zheng J, Man	Cell Rep Med	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancie [PMID:19821156]	Molvarec A, Tamási L, Losonczy G, Madách	Cell Stress Chaperones	2010	1
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Integrating NHANES and network toxicology to assess the impact of organophosphat [PMID:41804832]	Dai K, Huang Y, Cai H, Zhong G, Xie Z, W	Toxicology mechanisms and meth	2026	0
Crystal structures reveal phosphorylation-dependent disruption of the heat shock [PMID:41833837]	Stewart M, Paththamperuma C, McCann C, C	Cell stress & chaperones	2026	0
Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbat [PMID:41725010]	Wen M, Li J, Li Y, Hun M, Yang T, Meng Y	Cell & bioscience	2026	0
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via ne [PMID:41539636]	["Fu X", "Long Q", "Wang Z", "Yan S", "L	Journal of ethnopharmacology	2026	0
Single-cell transcriptomics reveal heat shock protein dysregulation in severe SA [PMID:41772029]	Suzuki T, Sato Y, Suzuki M, Fukuda Y, Iw	Scientific reports	2026	0

CAT

Understanding Entity Pages

Summary

Wiki Pages (21)

CAT — Catalase

NRF2 Oxidative Stress Pathway

oxidative-stress-comparison

Niemann-Pick Disease Type C (NPC)

prion-disease

cynata-therapeutics

Section 156: Pet Therapy and Animal-Assisted Interventions in CBS/PSP

visual-cortex-layer-2-3-neurons

semantic-dementia

KDM3A Gene (JMJD1A)

FOXO4 — Forkhead Box O4

Prion Protein

Multifocal Motor Neuropathy (MMN)

niemann-pick-disease

Arbor Biotechnologies

Sandhoff Disease

GBA Gene Mutations and Parkinson's Disease Risk

CTS Gene - Cathepsin S

KEAP1 Protein

TNF Signaling Pathway in Neurodegeneration

Pontocerebellar Pathway

Pathway Diagram

Outgoing (962)

Incoming (432)

Targeting Hypotheses (21)

Mentioning Analyses (30)

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What are the specific circulating factors in exercise-conditioned plasma that me

What genetic risk factors predispose individuals to developing CTE following rep

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

What signals trigger microglia to specifically recognize and phagocytose LC axon

How do the seven novel ALS genes function in animal models to cause neurodegener

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

Which tau PTMs are both disease-specific and druggable with selective small mole

Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

Which specific post-translational modifications create druggable epitopes unique

Which specific post-translational modifications distinguish pathological from ph

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Which specific post-translational modifications on pathological tau create drugg

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

How do dilncRNAs specifically drive molecular crowding and phase separation of D

What mechanisms underlie neuronal resistance to autophagy induction compared to

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

How can AQP4 be effectively targeted therapeutically to improve neurological out

How do perivascular cells specifically recognize and respond to amyloid-β to upr

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Epigenetic reprogramming in aging neurons

Trans-synaptic tau spreading and propagation mechanisms in AD

Quantitative proteomics of the aging synapse in early Alzheimer disease

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Related Papers (20)