| Gene Symbol | OGG1 |
| Aliases | OGG1PROTEIN |
| Chromosome | 3p26.2<br> |
| Function | OGG1 is a bifunctional DNA glycosylase that both excises 8-oxoG from damaged DNA and cleaves the abasic site that remains. |
| Primary Expression | all brain regions with highest levels in: - Hippocampus (dentate gyrus, CA3) - Cerebral cortex (layer V pyramidal neuron |
| Subcellular Localization | ** Nucleus, Mitochondria<br> [@klungland2017] |
| Molecular Weight | 39 kDa |
| Pathways | Autophagy, Dna Repair, Mitophagy, Mtor, Oxidative Stress |
| UniProt ID | O15527 |
| NCBI Gene ID | 4967 |
| Ensembl ID | ENSG00000114026 |
| GeneCards | OGG1 |
| Human Protein Atlas | OGG1 |
| N-terminal region | Contains mitochondrial targeting sequence (for mtOGG1 isoform) |
| DNA-binding domain | Helix-hairpin-helix (HhH) motif for DNA recognition |
| Associated Diseases | neurodegeneration, neuroinflammation |
| Interactions | AGING, AUTOPHAGY, Aβ42 oligomers, BDNF, BLM, DNA |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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