gene

BLM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections
0Hypotheses
0Analyses
50Outgoing
37Incoming

Summary

BLM is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Anxiety. Connected to 88 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolBLM
Full NameBloom Syndrome Protein
FunctionBLM is a 3'-5' DNA helicase with multiple cellular functions:
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Dna Repair
Ensembl IDENSG00000197299
GeneCardsBLM
Human Protein AtlasBLM
Associated DiseasesFibrosis, Pulmonary Fibrosis
InteractionsCX3CL1, STAT3, MTOR, PI3K, SNAP25, STX11
KG Connections138 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

BLM — Bloom Syndrome Protein

gene · 622 words

FANCM Protein

protein · 1683 words

FANCM Gene

gene · 1683 words

MRE11A Protein

protein · 1312 words

OGG1 Gene

gene · 787 words

RECQL4 Protein

protein · 543 words

Pathway Diagram

graph TD
    BLM["<b>BLM</b>"]
    Inflammation{"Inflammation"}
    BLM -->|"activates"| Inflammation
    Fibrosis{"Fibrosis"}
    BLM -->|"activates"| Fibrosis
    Als{"Als"}
    BLM -->|"activates"| Als
    Ms{"Ms"}
    BLM -->|"activates"| Ms
    BLM -->|"inhibits"| Als
    BLM -->|"inhibits"| Fibrosis
    Anxiety{"Anxiety"}
    BLM -->|"activates"| Anxiety
    Depression{"Depression"}
    BLM -->|"activates"| Depression
    Aging{"Aging"}
    BLM -->|"activates"| Aging
    Cancer{"Cancer"}
    BLM -->|"regulates"| Cancer
    BLM -->|"expressed in"| Als
    CX3CL1["CX3CL1"]
    BLM -->|"activates"| CX3CL1
    RAGE["RAGE"]
    RAGE -->|"activates"| BLM
    LGALS3["LGALS3"]
    LGALS3 -->|"activates"| BLM
    AKT["AKT"]
    AKT -->|"activates"| BLM
    MTOR["MTOR"]
    MTOR -->|"activates"| BLM
    PI3K["PI3K"]
    PI3K -->|"activates"| BLM
    STX11["STX11"]
    STX11 -->|"activates"| BLM
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| BLM
    MYC["MYC"]
    MYC -->|"inhibits"| BLM
    CANCER["CANCER"]
    CANCER -->|"regulates"| BLM
    ATM["ATM"]
    ATM -->|"activates"| BLM
    PDGFB["PDGFB"]
    PDGFB -->|"expressed in"| BLM
    style BLM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (101)

TargetRelationTypeStr
oxidative stress responseparticipates_inpathway0.80
Fibrosisactivatesdisease0.75
Fibrosisinhibitsdisease0.75
Autophagyactivatespathway0.70
CGAS-STINGactivatesgene0.70

Incoming (37)

SourceRelationTypeStr
PI3Kactivatesgene0.70
RAGEactivatesgene0.60
LGALS3activatesgene0.60
AKTactivatesgene0.60
MTORactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found