Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BLM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BLM is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Anxiety. Connected to 88 entities in the SciDEX knowledge graph.
| Gene Symbol | BLM |
| Full Name | Bloom Syndrome Protein |
| Function | BLM is a 3'-5' DNA helicase with multiple cellular functions: |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Dna Repair |
| Ensembl ID | ENSG00000197299 |
| GeneCards | BLM |
| Human Protein Atlas | BLM |
| Associated Diseases | Fibrosis, Pulmonary Fibrosis |
| Interactions | CX3CL1, STAT3, MTOR, PI3K, SNAP25, STX11 |
| KG Connections | 138 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BLM["<b>BLM</b>"]
Inflammation{"Inflammation"}
BLM -->|"activates"| Inflammation
Fibrosis{"Fibrosis"}
BLM -->|"activates"| Fibrosis
Als{"Als"}
BLM -->|"activates"| Als
Ms{"Ms"}
BLM -->|"activates"| Ms
BLM -->|"inhibits"| Als
BLM -->|"inhibits"| Fibrosis
Anxiety{"Anxiety"}
BLM -->|"activates"| Anxiety
Depression{"Depression"}
BLM -->|"activates"| Depression
Aging{"Aging"}
BLM -->|"activates"| Aging
Cancer{"Cancer"}
BLM -->|"regulates"| Cancer
BLM -->|"expressed in"| Als
CX3CL1["CX3CL1"]
BLM -->|"activates"| CX3CL1
RAGE["RAGE"]
RAGE -->|"activates"| BLM
LGALS3["LGALS3"]
LGALS3 -->|"activates"| BLM
AKT["AKT"]
AKT -->|"activates"| BLM
MTOR["MTOR"]
MTOR -->|"activates"| BLM
PI3K["PI3K"]
PI3K -->|"activates"| BLM
STX11["STX11"]
STX11 -->|"activates"| BLM
BNIP3["BNIP3"]
BNIP3 -->|"activates"| BLM
MYC["MYC"]
MYC -->|"inhibits"| BLM
CANCER["CANCER"]
CANCER -->|"regulates"| BLM
ATM["ATM"]
ATM -->|"activates"| BLM
PDGFB["PDGFB"]
PDGFB -->|"expressed in"| BLM
style BLM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| oxidative stress response | participates_in | pathway | 0.80 |
| Fibrosis | activates | disease | 0.75 |
| Fibrosis | inhibits | disease | 0.75 |
| Autophagy | activates | pathway | 0.70 |
| CGAS-STING | activates | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| Inflammation | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Pulmonary Fibrosis | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Pulmonary Fibrosis | associated_with | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Pulmonary Fibrosis | activates | disease | 0.65 |
| Breast Cancer | activates | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Senescence | inhibits | disease | 0.65 |
| CX3CL1 | activates | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| SNAP25 | activates | gene | 0.60 |
| STX11 | activates | gene | 0.60 |
| TBK1 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| JNK1 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| PARKIN | activates | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| TEAD1 | inhibits | gene | 0.60 |
| PRDX3 | inhibits | gene | 0.60 |
| YAP1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| SPP1 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| YAP1 | inhibits | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 0.70 |
| RAGE | activates | gene | 0.60 |
| LGALS3 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| STX11 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| MYC | inhibits | gene | 0.60 |
| ATM | activates | gene | 0.60 |
| PDGFB | expressed_in | gene | 0.60 |
| BAX | inhibits | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| OGG1 | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| SNAP25 | activates | gene | 0.60 |
| PRDX3 | inhibits | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| INFLAMMATION | inhibits | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| CYTOKINES | inhibits | gene | 0.60 |
| NF-ΚB | inhibits | gene | 0.60 |
| IL-6 | inhibits | gene | 0.60 |
| TNF-Α | inhibits | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||