protein 606 words KG: PDPK1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

3-Phosphoinositide Dependent Protein Kinase 1

🔬 Protein Info
Gene SymbolPDPK1PROTEIN
Full Name3-Phosphoinositide Dependent Kinase 1
Protein TypeProtein
Functionis a serine/threonine kinase that activates AKT and other AGC kinases.
Primary Expressioncancers and promotes cell survival and proliferation
Subcellular Localization** Cytoplasm, Plasma Membrane * **Protein Family:** AGC kinase family (3-phospho
Molecular Weight63 kDa
UniProt IDSearch UniProt
GeneCardsPDPK1PROTEIN
Human Protein AtlasPDPK1PROTEIN
Protein Kinase B (Akt)primary PDK1 substrate and central survival kinase
Phosphoinositide 3-Kinase (PI3K)upstream activator
Associated DiseasesInfection
InteractionsAKT, RSK2, S6K, FasL, TSC2, EIF4EBP1
KG Connections68 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in