| Gene Symbol | PLIN2 |
| Aliases | PLIN2PROTEIN |
| Chromosome | 9p22.1 |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | Lipid Storage: Promotes triglyceride storage by facilitating lipid droplet formation and preventing lipolysis [@brasaemle2004] |
| Mechanism of Action | Direct PLIN2 inhibitors would reduce lipid droplet formation and stability, promoting lipid mobilization and reducing pathological lipid accumulation. Indirect approaches target upstream regulators of PLIN2 expression or modulate associated lipases to alter lipid storage dynamics in metabolic and neurodegenerative disease states. |
| Subcellular Localization | </strong></td><td>Lipid droplet surface, endoplasmic reticulum</td></tr> |
| Druggability | Undruggable (0.23) |
| Clinical Stage | Approved |
| Molecular Weight | 46 kDa |
| Amino Acids | 437 aa |
| Pathways | Ferroptosis, Lipid Metabolism, Mitochondrial Function |
| UniProt ID | Q99541 |
| NCBI Gene ID | 107 |
| Ensembl ID | ENSG00000147872 |
| GeneCards | PLIN2 |
| Human Protein Atlas | PLIN2 |
| Associated Diseases | ALS, ALZHEIMER, Aging, Lipid Droplet Accumulation, Ms |
| Known Drugs/Compounds | rapamycin, riluzole |
| Interactions | NR1H3, TP53, PLIN3, STING1, GLP1R, SIRT3 |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Metabolic Circuit Breaker via Lipid Droplet Modula |
| KG Connections | 618 knowledge graph edges |
| Databases | GeneCardsHPASTRING |