| Gene Symbol | POLG |
| Full Name | DNA Polymerase Subunit Gamma |
| Chromosome | 15q25 |
| Protein Type | Tissues Affected |
| Function | POLG is the catalytic engine of the mitochondrial DNA replication machinery, one of the essential components of the mtDNA replisome that includes the helicase TWNK (Twinkle), the single-stranded DNA-b |
| Subcellular Localization | Mitochondria (mitochondrial matrix) |
| Molecular Weight | ~140 kDa |
| Amino Acids | 1239 aa |
| Pathways | Mitophagy |
| UniProt ID | Q9UQF2 |
| NCBI Gene ID | 5428 |
| Ensembl ID | ENSG00000140521 |
| OMIM | 174763 |
| GeneCards | POLG |
| Human Protein Atlas | POLG |
| Associated Diseases | ALS, Aging, Alzheimer's disease, Ataxia, Bipolar |
| Interactions | UCP2, POLG2, FANCD2, NCOA4, FERROPTOSIS, OXIDATIVE STRESS |
| KG Connections | 264 knowledge graph edges |
| Databases | GeneCardsHPASTRING |