| Gene Symbol | PON1PROTEIN |
| Chromosome | 7q21.3. |
| Protein Family | Paraoxonase family (PON1, PON2, PON3) |
| Function | is a calcium-dependent esterase primarily synthesized in the liver and associated with high-density lipoprotein (HDL) particles in plasma. |
| Primary Expression | neurons, astrocytes, and microglia, where it contributes to neuroprotection through multiple mechanisms including antioxidant activity, anti-inflammat |
| Subcellular Localization | Plasma (HDL-associated), Liver, Kidney |
| Molecular Weight | ~43 kDa (354 amino acids) |
| Amino Acids | 354 aa |
| Exons | 9 |
| UniProt ID | P27169 |
| GeneCards | PON1PROTEIN |
| Human Protein Atlas | PON1PROTEIN |
| Protein Name | Paraoxonase 1 |
| Gene | PON1 |
| Brain Expression | Cortex, Hippocampus, Cerebellum |
| Associated Diseases | Als, Atherosclerosis, Breast Cancer, Cancer, Depression, Inflammation |
| Interactions | CLU |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |