| Gene Symbol | PON1PROTEIN |
| Chromosome | 7q21.3. |
| Function | is a calcium-dependent esterase primarily synthesized in the liver and associated with high-density lipoprotein (HDL) particles in plasma. |
| Primary Expression | neurons, astrocytes, and microglia, where it contributes to neuroprotection through multiple mechanisms including antioxidant activity, anti-inflammat |
| Subcellular Localization | ** | Plasma (HDL-associated), Liver, Kidney | |
| Molecular Weight | 43 kDa |
| Amino Acids | 354 aa |
| Exons | 9 |
| GeneCards | PON1PROTEIN |
| Human Protein Atlas | PON1PROTEIN |
| Q192R (rs662) | Glutamine to arginine substitution at position 192, affecting substrate specificity and activity levels |
| L55M (rs854560) | Leucine to methionine substitution, influencing enzyme expression |
| C(-108)T (rs705379) | Promoter variant affecting transcription levels |
| Associated Diseases | Als, Atherosclerosis, Breast Cancer, Cancer, Depression, Inflammation |
| Interactions | CLU |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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