gene

CLU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1060Connections

2Hypotheses

12Analyses

50Outgoing

50Incoming

Summary

Clusterin (CLU/ApoJ) is an extracellular chaperone and the third most significant genetic risk factor for late-onset Alzheimer's disease. CLU binds amyloid-beta with high affinity, modulating its aggregation, clearance across the blood-brain barrier, and uptake by astrocytes and microglia. CLU also inhibits complement-mediated cell lysis and regulates apoptosis. AD risk variants in CLU alter its expression and splicing, reducing amyloid clearance efficiency. CLU levels are elevated in AD brain and CSF, serving as a potential biomarker. CLU cooperates with APOE in lipid transport and amyloid metabolism; the CLU-APOE interaction is a key node in AD pathogenesis.

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🧬 Gene Info

Gene Symbol	CLU
Full Name	Clusterin (Apolipoprotein J, ApoJ)
Aliases	Page for CLU Gene
Chromosome	8p21.1
Function	is a gene located on chromosome 8p21.
Primary Expression	Hippocampus, Cortex, Basal ganglia, Cerebellum
Exons	9
Pathways	Astrocyte Reactivity, Blood-Brain Barrier, Camp Signaling, Complement, Dysbiosis
UniProt ID	P10909
NCBI Gene ID	1115
Ensembl ID	ENSG00000120885
OMIM	185551
GeneCards	CLU
Human Protein Atlas	CLU
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Aging, Alzheimer, Alzheimer disease
Interactions	PPARGC1A, BAX, LC3, PPARG, C1Q, TREM2
KG Connections	1059 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CLU — AlphaFold P10909 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CLU["CLU"]
    CLU -->|"activates"| mitophagy["mitophagy"]
    CLU -->|"encodes"| clusterin["clusterin"]
    CLU -->|"activates"| neuronal_excitability["neuronal excitability"]
    CLU -->|"activates"| lipid_droplet_formation["lipid droplet formation"]
    CLU -->|"activates"| neuron_glia_lipid_transfer["neuron-glia lipid transfer"]
    CLU -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    CLU -->|"regulates"| Cancer["Cancer"]
    CLU -->|"interacts"| Alzheimer["Alzheimer"]
    CLU -->|"activates"| Als["Als"]
    BAX["BAX"] -->|"interacts"| CLU
    PPARG["PPARG"] -->|"activates"| CLU
    PPARGC1A["PPARGC1A"] -->|"activates"| CLU
    C1Q["C1Q"] -->|"activates"| CLU
    BIN1["BIN1"] -->|"activates"| CLU
    CDKN2A["CDKN2A"] -->|"expressed in"| CLU
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"expressed in"| CLU
    PRKCB["PRKCB"] -->|"expressed in"| CLU
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| CLU
    CANCER["CANCER"] -->|"expressed in"| CLU

Outgoing (727)

Target	Relation	Type	Str
ds-f50762b67605	provides_data_for	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Clu	encodes	entity	0.95
Mitophagy	associated_with	process	0.95
Alzheimer's Disease	risk_factor_for	disease	0.95
Mitochondrial Damage	modulates	process	0.90
Oral Cancer Cell Survival	contributes_to	phenotype	0.90
Astrocyte Reactivity	modulates	process	0.90
Amyloid Accumulation	inhibits	process	0.90
Fibrillar Amyloid	downregulates	compound	0.90
Amyloid Beta Aggregation	regulates	process	0.90
MITOPHAGY	controls	process	0.90
AMYLOID-Β	interacts_with	protein	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Cognitive Resilience	associated_with	phenotype	0.88
Autophagic Machinery	associated_with	mechanism	0.85
PPARGC1A	associated_with	gene	0.85
Mitochondrial Damage	inhibits	phenotype	0.85
NF-κB Signaling	inhibits	pathway	0.85
Complement pathway	component_of	pathway	0.85
Amyloid Metabolism	regulates	process	0.85
Neuronal Cell Death	inhibits	process	0.85
Alzheimer Disease	risk_factor_for	disease	0.85
Complement System	inhibits	pathway	0.85
C3	inhibits	protein	0.80
Cognitive Function	protects_against	phenotype	0.80
Memory	modulates	phenotype	0.80
Brain Inflammation	inhibits	process	0.80
Lipid Transport	mediates	process	0.80
Neuronal Apoptosis	modulates	process	0.80
Cognitive Aging	risk_factor_for	phenotype	0.80
Alzheimer'S Disease	associated_with	disease	0.80
oxidative stress response	participates_in	pathway	0.80
microglia	expressed_in	cell_type	0.80
Neuroinflammation	contributes_to	process	0.80
unfolded protein response	participates_in	pathway	0.80
lipid metabolism	involved_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Aβ	clears	protein	0.80
Wnt Signaling	modulates	pathway	0.75
Copper Homeostasis	regulates	process	0.75
Alzheimer	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Als	associated_with	disease	0.75
LC3	interacts_with	protein	0.74
CR1	associated_with	gene	0.74
mitophagy	activates	pathway	0.72
CLUSTERIN	regulates	gene	0.70
CR1	regulates	gene	0.70

Incoming (333)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
APOE	associated_with	gene	0.98
SORL1	regulates	gene	0.90
Astrocyte	expressed_in	cell_type	0.85
CD63	upregulates	gene	0.80
rs11136000	associated_with	biomarker	0.75
rs9331888	associated_with	biomarker	0.75
AMYLOID	associated_with	gene	0.74
Exercise	upregulates	process	0.70
APOE	modulates	gene	0.70
CD33	regulates	gene	0.70
BIN1	associated_with	gene	0.66
ALZHEIMER'S DISEASE	regulates	disease	0.66
ASTROCYTES	associated_with	cell_type	0.66
ABCA1	associated_with	gene	0.65
CD2AP	associated_with	gene	0.65
BDNF	co_discussed	gene	0.65
LRRK2	regulates	gene	0.65
AKT	co_discussed	gene	0.65
CD33	inhibits	gene	0.65
CD33	increases_risk	gene	0.65
AKT	treats	gene	0.65
ASTROCYTE	increases	cell_type	0.65
ASTROCYTES	increases	cell_type	0.65
MONOCYTES	interacts_with	cell_type	0.65
CORTEX	regulates	brain_region	0.65
NEUROINFLAMMATION	targets	phenotype	0.65
MICROGLIA	interacts_with	cell_type	0.65
PPARG	activates	gene	0.60
PPARGC1A	activates	gene	0.60
C1Q	activates	gene	0.60
CDKN2A	expressed_in	gene	0.60
PRKCB	expressed_in	gene	0.60
MMP3	associated_with	gene	0.60
SPP1	associated_with	gene	0.60
ACE	expressed_in	gene	0.60
NDUFS8	regulates	gene	0.60
LDLR	expressed_in	gene	0.60
CD4	associated_with	gene	0.60
LMNA	activates	gene	0.60
C1QA	activates	gene	0.60
LC3	interacts_with	gene	0.60
CLUSTERIN	regulates	gene	0.60
APOE	activates	gene	0.60
TREM2	associated_with	gene	0.60
TAU	associated_with	gene	0.60
TREM2	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CLU-APOE-TREM2 Tripartite Axis as a Coordinate Therapeutic T	0.548	neurodegeneration	Does clusterin exacerbate or protect aga
Magnetosonic-Triggered Transferrin Receptor Clustering	0.470	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (12)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623]	Chen S, Qi T, Peng H, Kimura E, Zhang X	J Control Release	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296]	Gong W, Hui W, Qiao S, Ji Q, Liu M et al	Adv Sci (Weinh)	2026	0
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413]	Palsa K, Sahu AP, Rye DB, Trotti LM, Elc	Ann Neurol	2026	0
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316]	Thakur A, Zhang K, Chen J, Mei S, Chen J	Sci Adv	2026	0
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599]	Zhang H, Li M, Zhang J, Sun Q, Jin X et	Free Radic Biol Med	2026	0
Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266]	Aygörmez S, Küçükler S, Çomaklı S, Şimşe	J Appl Toxicol	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0
Raccoon eyes. [PMID:35789012]	Ning J	Journal of paediatrics and chi	2023	0

CLU

Understanding Entity Pages

Summary

Wiki Pages (21)

CLU — Clusterin (Apolipoprotein J)

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

TREM2 Mechanism Hub

Synaptic Vesicle Trafficking in Parkinson's Disease

Pathway Diagram

Outgoing (727)

Incoming (333)

Targeting Hypotheses (2)

Mentioning Analyses (12)

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

Epigenetic reprogramming in aging neurons

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Senolytic therapy for age-related neurodegeneration

Related Papers (20)

CLU

Understanding Entity Pages

Summary

Wiki Pages (21)

CLU — Clusterin (Apolipoprotein J)

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

TREM2 Mechanism Hub

Synaptic Vesicle Trafficking in Parkinson's Disease

Epigenetic Alterations in Alzheimer's Disease

Amyloid Cascade Pathway

Gene-Mechanism-Therapy Causal Chains

Tauopathies

RNA Metabolism Dysregulation in Alzheimer's Disease

Amyloid-Beta Aggregation and Plaque Formation

genetics

Synaptic Plasticity Deficits in Neurodegeneration

neurovascular-dysfunction

AD Biomarker-to-Mechanism Mapping

Sporadic Alzheimer's Disease Pathway

CBS/PSP Genetic Architecture

Type 3 Diabetes Hypothesis of Alzheimer's Disease

CR1 Gene — Complement Component 1q Receptor

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

Pathway Diagram

Outgoing (727)

Incoming (333)

Targeting Hypotheses (2)

Mentioning Analyses (12)

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

What determines the specificity of DDR protein recruitment to dilncRNA-induced c

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

Epigenetic reprogramming in aging neurons

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Extracellular vesicle biomarkers for early AD detection

Senolytic therapy for age-related neurodegeneration

Related Papers (20)