| Gene Symbol | PRKACA |
| Aliases | PRKACAPROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </b></td><td>Cytosol, nucleus, plasma membrane</td></tr> |
| Molecular Weight | 40.6 kDa |
| Pathways | mTOR, mtor |
| GeneCards | PRKACA |
| Human Protein Atlas | PRKACA |
| N-terminal helix | Regulatory interaction and autoinhibitory function |
| Catalytic core | Kinase domain (residues 40-300) containing the active site |
| Glycine-rich loop | Phosphate transfer and ATP binding (residues 50-55) |
| Activation segment | Phosphorylation site at Thr197, required for full activity |
| C-terminal tail | Docking and regulatory interactions |
| Active conformation | Bound to ATP and substrate analogs (PDB: 1J3H) |
| Inactive conformation | With bound inhibitors (PDB: 1J3I) |
| Associated Diseases | Infection, Inflammation, Sepsis |
| Interactions | Actin, CAV1, CAVEOLIN-1, CPT1A, Ras, Ubiquitin |
| KG Connections | 83 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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