concept

CPT1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPT1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

190Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CPT1A
Related Diseases	immunotherapy resistance, Ischemia, Metabolic Syndrome, Tumor, Cancer
Related Pathways	fatty acid oxidation

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CPT1A["CPT1A"]
    style CPT1A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CPT1A -->|"regulates"| fatty_acid_oxidation["fatty acid oxidation"]
    CPT1A -.->|"inhibits"| ferroptosis["ferroptosis"]
    CPT1A -->|"promotes"| immunotherapy_resistance(immunotherapy resistance)
    CPT1A -->|"regulates"| Ischemia["Ischemia"]
    CPT1A -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CPT1A -->|"activates"| Tumor["Tumor"]
    CPT1A -->|"activates"| Cancer["Cancer"]
    CPT1A -.->|"inhibits"| Fibrosis["Fibrosis"]
    CPT1A -.->|"inhibits"| Inflammation["Inflammation"]
    CPT1A -.->|"inhibits"| Hepatitis["Hepatitis"]
    PLIN2([PLIN2]) -->|"binds"| CPT1A
    L_carnitine{"L-carnitine"} -->|"interacts"| CPT1A
    LAMP1([LAMP1]) -->|"regulates"| CPT1A
    RAB7A([RAB7A]) -->|"regulates"| CPT1A
    PPARA([PPARA]) -->|"regulates"| CPT1A
    MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| CPT1A
    RAS([RAS]) -->|"regulates"| CPT1A
    EIF4EBP1([EIF4EBP1]) -->|"regulates"| CPT1A
    MAP1LC3B([MAP1LC3B]) -->|"regulates"| CPT1A

Outgoing (131)

Target	Relation	Type	Str
fatty acid oxidation	regulates	pathway	0.95
ferroptosis	inhibits	process	0.90
lipid droplet-mitochondria tethering	mediates	process	0.90
immunotherapy resistance	promotes	phenotype	0.85
Lipid Oxidation	involved_in	process	0.80
Ischemia	regulates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Als	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
LRP2	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
RPS6	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ATP	regulates	gene	0.60
EGFR	regulates	gene	0.60
AND	regulates	gene	0.60
MTORC1	regulates	gene	0.60
MYC	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
PPARG	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
CTSD	regulates	gene	0.60
SREBF1	regulates	gene	0.60
ATG	regulates	gene	0.60
MTOR	regulates	gene	0.60
CAT	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
CANCER	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
ALOX15	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FASN	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
ROS	inhibits	gene	0.60

Incoming (59)

Source	Relation	Type	Str
PLIN2	binds_to	entity	0.90
h-edfd6c89	targets_gene	hypothesis	0.90
L-carnitine	interacts_with	drug	0.85
LAMP1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RAS	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PLIN2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
JUN	activates	gene	0.60
AND	activates	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
PRKACA	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
ROS	inhibits	gene	0.60
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
CTSD	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
MTOR	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
CAT	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
EGFR	regulates	gene	0.60
RPS6	regulates	gene	0.60
ATG	regulates	gene	0.60
LRP2	regulates	gene	0.60
ATP	regulates	gene	0.60
ALOX15	inhibits	gene	0.60
FASN	inhibits	gene	0.60
PPAR	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CAV1	inhibits	gene	0.60
CDH1	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
CACNB3	associated_with	gene	0.60
ADRB1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CPT1A

Understanding Entity Pages

Wiki Pages (4)

Lipid Metabolism Dysregulation in Neurodegeneration

PPAR Signaling Pathway in Neurodegeneration