concept

CPT1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPT1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

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💡 Concept Info

Name	CPT1A
Key Genes/Proteins	ACACA, ACSL4, ACTB, Actin, ADRB1, AGING
Related Diseases	Aging, Als, ALS
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CPT1A["CPT1A"]
    style CPT1A fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CPT1A -->|"regulates"| fatty_acid_oxidation["fatty acid oxidation"]
    CPT1A -.->|"inhibits"| ferroptosis["ferroptosis"]
    CPT1A -->|"promotes"| immunotherapy_resistance(immunotherapy resistance)
    CPT1A -->|"regulates"| Ischemia["Ischemia"]
    CPT1A -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    CPT1A -->|"activates"| Tumor["Tumor"]
    CPT1A -->|"activates"| Cancer["Cancer"]
    CPT1A -.->|"inhibits"| Fibrosis["Fibrosis"]
    CPT1A -.->|"inhibits"| Inflammation["Inflammation"]
    CPT1A -.->|"inhibits"| Hepatitis["Hepatitis"]
    PLIN2([PLIN2]) -->|"binds"| CPT1A
    L_carnitine{"L-carnitine"} -->|"interacts"| CPT1A
    LAMP1([LAMP1]) -->|"regulates"| CPT1A
    RAB7A([RAB7A]) -->|"regulates"| CPT1A
    PPARA([PPARA]) -->|"regulates"| CPT1A
    MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| CPT1A
    RAS([RAS]) -->|"regulates"| CPT1A
    EIF4EBP1([EIF4EBP1]) -->|"regulates"| CPT1A
    MAP1LC3B([MAP1LC3B]) -->|"regulates"| CPT1A

Outgoing (130)

Target	Relation	Type	Str
fatty acid oxidation	regulates	pathway	0.95
ferroptosis	inhibits	process	0.90
lipid droplet-mitochondria tethering	mediates	process	0.90
immunotherapy resistance	promotes	phenotype	0.85
Lipid Oxidation	involved_in	process	0.80
Carcinoma	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Ischemia	regulates	disease	0.65
Tumor	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Cancer	activates	disease	0.65
MYC	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
PPARG	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
CTSD	regulates	gene	0.60
SREBF1	regulates	gene	0.60
ATG	regulates	gene	0.60
MTOR	regulates	gene	0.60
CAT	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
CANCER	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
ALOX15	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
FASN	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
ROS	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
BAX	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
GENES	inhibits	gene	0.60
Necroptosis	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60

Incoming (58)

Source	Relation	Type	Str
h-edfd6c89	targets_gene	hypothesis	0.90
PLIN2	binds_to	entity	0.90
L-carnitine	interacts_with	drug	0.85
PPARG	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
SREBF1	regulates	gene	0.60
CTSD	regulates	gene	0.60
NADH	regulates	gene	0.60
ACTB	regulates	gene	0.60
ALOX15	inhibits	gene	0.60
FASN	inhibits	gene	0.60
PPAR	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CAV1	inhibits	gene	0.60
ACACA	activates	gene	0.60
ALDH2	activates	gene	0.60
SCD1	inhibits	gene	0.60
MTOR	regulates	gene	0.60
MTORC1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
CAT	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
RUBCN	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
EGFR	regulates	gene	0.60
RPS6	regulates	gene	0.60
ATG	regulates	gene	0.60
LRP2	regulates	gene	0.60
ATP	regulates	gene	0.60
CDH1	therapeutic_target	gene	0.60
PER	therapeutic_target	gene	0.60
CACNB3	associated_with	gene	0.60
ADRB1	associated_with	gene	0.60
AGING	therapeutic_target	gene	0.60
CPT2	associated_with	gene	0.60
LAMP1	regulates	gene	0.60
RAB7A	regulates	gene	0.60
PPARA	regulates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RAS	regulates	gene	0.60
EIF4EBP1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
PLIN2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
JUN	activates	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fatty Acid Metabolism Enhancers for Activity-Dependent Neuro	0.000	-	Mitochondrial transfer between astrocyte

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
High fat diet aging study in CPT1A knockout mice	validation	kidney aging and metabolic dys	0.850	0.00	conditional CPT1A knockout mic	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Mitochondrial transfer between astrocytes and neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning CPT1A in their description or question text

No additional research found