| Gene Symbol | RORAPROTEIN |
| Protein Type | Receptor |
| Function | is a nuclear receptor transcription factor encoded by the RORA gene. |
| Primary Expression | the brain: - Cerebellum: Purkinje cells show highest expression - Hippocampus: CA1-CA3 pyramidal [neurons](/enti |
| Molecular Weight | 59 kDa |
| GeneCards | RORAPROTEIN |
| Human Protein Atlas | RORAPROTEIN |
| N-terminal activation domain (AF-1) | Contains phosphorylation sites for regulation |
| DNA-binding domain (DBD) | Two zinc finger motifs that recognize ROREs |
| Hinge region | Flexible linker connecting DBD to LBD |
| Ligand-binding domain (LBD) | Binds heme, cholesterol, and other ligands |
| C-terminal activation domain (AF-2) | Required for transcriptional coactivator recruitment |
| Heme | Binds with micromolar affinity, may link to metabolic state |
| Cholesterol | Potential endogenous ligand |
| Retinoids | All-trans retinoic acid may modulate activity |
| Associated Diseases | Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes |
| Interactions | Actin, ALZHEIMER, ALZHEIMER'S DISEASE, App, APP, AUTOPHAGY |
| KG Connections | 122 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!