protein 1,537 words KG: TFPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Transferrin Protein

🔬 Protein Info
Gene SymbolTFPROTEIN
Full NameTransferrin
Protein FamilyTransferrin family
Functionis an 80 kDa iron-binding glycoprotein that plays essential roles in systemic and cellular iron homeostasis.
Subcellular LocalizationSecreted, extracellular
Molecular Weight~80 kDa
Amino Acids679 aa
UniProt IDP02787
GeneCardsTFPROTEIN
Human Protein AtlasTFPROTEIN
Protein NameTransferrin
GeneTF
PDB ID1BP5, 1JTF
Iron-binding capacity2 Fe³⁺ ions per molecule
ProteinRole in Brain Iron Metabolism
Associated Diseasesneurodegeneration
InteractionsTP53, WNT, MYC, OCT4
KG Connections29 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (22)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

Related Experiments (3)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson'
clinical · proposed · Score: 0.40

Key Papers (2)

Assessment of the Spatial Distribution of Moisture Content in Granular
Sensors (Basel, Switzerland) 2024
Corpus callosotomy for treatment of drug-resistant epilepsy: a review
Journal of neurosurgery. Pedia 2020

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 32 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 32 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 32 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 32 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 32 hypotheses