protein 609 words KG: TK2
Contents

Thymidine Kinase 2 Protein

🔬 Protein Info
Gene SymbolTK2
Full NameThymidine Kinase 2
Chromosome16q22.1
Protein TypeProtein
FunctionThymidine kinase 2 (TK2) is a mitochondrial enzyme that catalyzes the phosphorylation of thymidine, deoxyuridine, and deoxycytidine.
Subcellular Localizationmitochondria, where it plays a critical role in maintaining the mitochondrial deoxynucleotide (dNTP) pool—a process esse
Molecular Weight62 kDa
Amino Acids265 aa
UniProt IDSearch UniProt
GeneCardsTK2
Human Protein AtlasTK2
Associated Diseasesneurodegeneration
KG Connections28 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

Mitochondria
entity · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with
Genes
index · KG edge: associated_with
DGUOK — Deoxyguanosine Kinase
gene · KG edge: associated_with
mfn2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

POLG2 associated_with TK2
SLC25A4 associated_with TK2
MFN2 associated_with TK2
TYMP associated_with TK2
RRM2B associated_with TK2
TK2 associated_with SUCLA2
TK2 associated_with SUCLG1
TK2 associated_with TFAM
TK2 associated_with POLG
TK2 associated_with RNASEH1

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