gene 2,035 words KG: RRM2B 2026-03-27
kind:genesection:genesstate:published
Contents

RRM2B Gene

🧬 Gene Info
Gene SymbolRRM2B
Full NameRibonucleotide Reductase Regulatory TP53 Inducible Subunit M2B
AliasesRRM2B gene encoding p53-inducible ribonucleotide reductase subunit M2B
Chromosome8q23.1
Protein TypeEnzyme
Functionencodes a critical enzyme in nucleotide metabolism, specifically the p53-inducible small subunit of ribonucleotide reductase (RNR).
Primary Expressionmost human tissues, with highest levels in: - Skeletal muscle: High mitochondrial content and energy demand - Heart: Continuous oxidative phos
Molecular Weight~45 kDa
Amino Acids389 aa
UniProt IDQ7LG56
NCBI Gene ID50484
Ensembl IDENSG00000068912
OMIM604712
GeneCardsRRM2B
Human Protein AtlasRRM2B
Associated Diseasesneurodegeneration
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: expressed_in
TWNK Gene
gene · KG edge: associated_with
TK2 Gene
gene · KG edge: associated_with
TFAM Gene
gene · KG edge: associated_with
SUCLG1 — Succinate-CoA Ligase GDP Forming Subunit Alpha
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RRM2B associated_with TK2
RRM2B associated_with SUCLA2
RRM2B associated_with SUCLG1
RRM2B associated_with TFAM
RRM2B associated_with POLG
RRM2B associated_with RNASEH1
RRM2B associated_with OPA1
RRM2B associated_with TWNK
RRM2B associated_with MPV17
RRM2B associated_with DGUOK